Gastric electrical stimulation is safe and effective

A long-term study in patients with drug-refractory gastroparesis in three regional centers

Curuchi Anand, Amar Al-Juburi, Babajide Familoni, Hani Rashed, Teresa Cutts, Nighat Abidi, William D. Johnson, Anil Minocha, Thomas L. Abell

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Drug-refractory gastroparesis has previously been without acceptable alternative therapies. Although gastric electrical stimulation has been used for over a decade, no long-term multicenter data exist. Methods: We studied 214 consecutive drug-refractory patients with the symptoms of gastroparesis (146 idiopathic, 45 diabetic, 23 after surgery) who consented to participate in a variety of clinical research and clinical protocols at three centers from January 1992 through January 2005, resulting in 156 patients implanted with a gastric electrical stimulation device and the other 58 patients serving as controls. The patients were stratified into three groups: (1) consented but never permanently implanted; (2) implanted with permanent device, and (3) consented while awaiting a permanent device. The patients were followed over time for gastrointestinal symptoms, solid gastric emptying, health-related quality of life, survival, device retention, and complications. Demographics, descriptive statistics, and t tests were used for comparison between baseline and latest follow-up. Results: At latest follow-up, median 4 years for 5,568 patient months, most patients implanted (135 of 156) were alive with intact devices, significantly reduced gastrointestinal symptoms, and improved health-related quality of life, with evidence of improved gastric emptying, and 90% of the patients had a response in at least 1 of 3 main symptoms. Most patients explanted, usually for pocket infections, were later reimplanted successfully. There were no deaths directly related to the device. Conclusion: Based on this sample of patients, implanted with gastric electrical stimulation devices at three centers and followed for up toward a decade, gastric electrical stimulation for drug-refractory gastroparesis is both safe and effective.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalDigestion
Volume75
Issue number2-3
DOIs
StatePublished - Aug 2007
Externally publishedYes

Fingerprint

Gastroparesis
Electric Stimulation
Stomach
Pharmaceutical Preparations
Equipment and Supplies
Gastric Emptying
Quality of Life
Complementary Therapies
Clinical Protocols
Demography

Keywords

  • Drug-refractory gastroparesis
  • Gastric electrical stimulation
  • Long-term multicenter study, gastroparesis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastric electrical stimulation is safe and effective : A long-term study in patients with drug-refractory gastroparesis in three regional centers. / Anand, Curuchi; Al-Juburi, Amar; Familoni, Babajide; Rashed, Hani; Cutts, Teresa; Abidi, Nighat; Johnson, William D.; Minocha, Anil; Abell, Thomas L.

In: Digestion, Vol. 75, No. 2-3, 08.2007, p. 83-89.

Research output: Contribution to journalArticle

Anand, Curuchi ; Al-Juburi, Amar ; Familoni, Babajide ; Rashed, Hani ; Cutts, Teresa ; Abidi, Nighat ; Johnson, William D. ; Minocha, Anil ; Abell, Thomas L. / Gastric electrical stimulation is safe and effective : A long-term study in patients with drug-refractory gastroparesis in three regional centers. In: Digestion. 2007 ; Vol. 75, No. 2-3. pp. 83-89.
@article{6bbb16f507064462930c3feb1a5ecb43,
title = "Gastric electrical stimulation is safe and effective: A long-term study in patients with drug-refractory gastroparesis in three regional centers",
abstract = "Background: Drug-refractory gastroparesis has previously been without acceptable alternative therapies. Although gastric electrical stimulation has been used for over a decade, no long-term multicenter data exist. Methods: We studied 214 consecutive drug-refractory patients with the symptoms of gastroparesis (146 idiopathic, 45 diabetic, 23 after surgery) who consented to participate in a variety of clinical research and clinical protocols at three centers from January 1992 through January 2005, resulting in 156 patients implanted with a gastric electrical stimulation device and the other 58 patients serving as controls. The patients were stratified into three groups: (1) consented but never permanently implanted; (2) implanted with permanent device, and (3) consented while awaiting a permanent device. The patients were followed over time for gastrointestinal symptoms, solid gastric emptying, health-related quality of life, survival, device retention, and complications. Demographics, descriptive statistics, and t tests were used for comparison between baseline and latest follow-up. Results: At latest follow-up, median 4 years for 5,568 patient months, most patients implanted (135 of 156) were alive with intact devices, significantly reduced gastrointestinal symptoms, and improved health-related quality of life, with evidence of improved gastric emptying, and 90{\%} of the patients had a response in at least 1 of 3 main symptoms. Most patients explanted, usually for pocket infections, were later reimplanted successfully. There were no deaths directly related to the device. Conclusion: Based on this sample of patients, implanted with gastric electrical stimulation devices at three centers and followed for up toward a decade, gastric electrical stimulation for drug-refractory gastroparesis is both safe and effective.",
keywords = "Drug-refractory gastroparesis, Gastric electrical stimulation, Long-term multicenter study, gastroparesis",
author = "Curuchi Anand and Amar Al-Juburi and Babajide Familoni and Hani Rashed and Teresa Cutts and Nighat Abidi and Johnson, {William D.} and Anil Minocha and Abell, {Thomas L.}",
year = "2007",
month = "8",
doi = "10.1159/000102961",
language = "English (US)",
volume = "75",
pages = "83--89",
journal = "Digestion",
issn = "0012-2823",
publisher = "S. Karger AG",
number = "2-3",

}

TY - JOUR

T1 - Gastric electrical stimulation is safe and effective

T2 - A long-term study in patients with drug-refractory gastroparesis in three regional centers

AU - Anand, Curuchi

AU - Al-Juburi, Amar

AU - Familoni, Babajide

AU - Rashed, Hani

AU - Cutts, Teresa

AU - Abidi, Nighat

AU - Johnson, William D.

AU - Minocha, Anil

AU - Abell, Thomas L.

PY - 2007/8

Y1 - 2007/8

N2 - Background: Drug-refractory gastroparesis has previously been without acceptable alternative therapies. Although gastric electrical stimulation has been used for over a decade, no long-term multicenter data exist. Methods: We studied 214 consecutive drug-refractory patients with the symptoms of gastroparesis (146 idiopathic, 45 diabetic, 23 after surgery) who consented to participate in a variety of clinical research and clinical protocols at three centers from January 1992 through January 2005, resulting in 156 patients implanted with a gastric electrical stimulation device and the other 58 patients serving as controls. The patients were stratified into three groups: (1) consented but never permanently implanted; (2) implanted with permanent device, and (3) consented while awaiting a permanent device. The patients were followed over time for gastrointestinal symptoms, solid gastric emptying, health-related quality of life, survival, device retention, and complications. Demographics, descriptive statistics, and t tests were used for comparison between baseline and latest follow-up. Results: At latest follow-up, median 4 years for 5,568 patient months, most patients implanted (135 of 156) were alive with intact devices, significantly reduced gastrointestinal symptoms, and improved health-related quality of life, with evidence of improved gastric emptying, and 90% of the patients had a response in at least 1 of 3 main symptoms. Most patients explanted, usually for pocket infections, were later reimplanted successfully. There were no deaths directly related to the device. Conclusion: Based on this sample of patients, implanted with gastric electrical stimulation devices at three centers and followed for up toward a decade, gastric electrical stimulation for drug-refractory gastroparesis is both safe and effective.

AB - Background: Drug-refractory gastroparesis has previously been without acceptable alternative therapies. Although gastric electrical stimulation has been used for over a decade, no long-term multicenter data exist. Methods: We studied 214 consecutive drug-refractory patients with the symptoms of gastroparesis (146 idiopathic, 45 diabetic, 23 after surgery) who consented to participate in a variety of clinical research and clinical protocols at three centers from January 1992 through January 2005, resulting in 156 patients implanted with a gastric electrical stimulation device and the other 58 patients serving as controls. The patients were stratified into three groups: (1) consented but never permanently implanted; (2) implanted with permanent device, and (3) consented while awaiting a permanent device. The patients were followed over time for gastrointestinal symptoms, solid gastric emptying, health-related quality of life, survival, device retention, and complications. Demographics, descriptive statistics, and t tests were used for comparison between baseline and latest follow-up. Results: At latest follow-up, median 4 years for 5,568 patient months, most patients implanted (135 of 156) were alive with intact devices, significantly reduced gastrointestinal symptoms, and improved health-related quality of life, with evidence of improved gastric emptying, and 90% of the patients had a response in at least 1 of 3 main symptoms. Most patients explanted, usually for pocket infections, were later reimplanted successfully. There were no deaths directly related to the device. Conclusion: Based on this sample of patients, implanted with gastric electrical stimulation devices at three centers and followed for up toward a decade, gastric electrical stimulation for drug-refractory gastroparesis is both safe and effective.

KW - Drug-refractory gastroparesis

KW - Gastric electrical stimulation

KW - Long-term multicenter study, gastroparesis

UR - http://www.scopus.com/inward/record.url?scp=34548316019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548316019&partnerID=8YFLogxK

U2 - 10.1159/000102961

DO - 10.1159/000102961

M3 - Article

VL - 75

SP - 83

EP - 89

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 2-3

ER -