Gastric cancer nodal metastases: Biologic significance and therapeutic considerations

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Stage migration as well as marked variation in stage distribution confounds the direct comparison of survival rates associated with varying degrees of lymphadenectomy for gastric cancer. Data from prospective randomized trials document increased mortality and morbidity associated with D-2 lymphadenectomy. Evidence for improved survival with D-2 lymphadenectomy comes from retrospective and prospective nonrandomized studies that have yet to be validated by any prospective randomized trial. Although it is of value for accurate staging, D-2 lymphadenectomy has yet to be proven therapeutically superior to D-1 resection.

Original languageEnglish (US)
Pages (from-to)129-144
Number of pages16
JournalSurgical Oncology Clinics of North America
Issue number1
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Surgery


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