Gastric acid secretion in Basenji dogs with immunoproliferative enteropathy.

E. B. Breitschwerdt, Nigel J Maclachlan, R. A. Argenzio, S. A. Hurlbert, C. Babineau, E. V. De Buysscher

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Gastric acid secretion was studied in 13 Basenji dogs with immunoproliferative enteropathy. Considerable variation in the severity of gastritis and enteritis existed among dogs. Basenji dogs were categorized into two groups on the basis of postmortem gastric and intestinal histology (group I, gastritis and enteritis; group II, only enteritis). Pentagastrin-induced gastric acid secretory capacity was increased (P less than 0.002) in group II dogs as compared to healthy Beagle controls. Gastric acid secretory capacity of Basenji dogs with gastritis and enteritis (group I) was not different from that observed in control dogs. Basal serum gastrin concentrations and secretin-stimulated serum gastrin concentrations of either group of Basenji dogs did not differ from controls. On the basis of symptomatology, Basenji dogs with diarrhea had significantly increased basal and postsecretin stimulation gastrin concentrations (P = 0.01) when compared with asymptomatic Basenji or healthy control dogs. These findings support a potential role for altered gastric acid secretory capacity in the pathogenesis of immunoproliferative enteropathy of Basenji dogs. Results of the secretin stimulation studies support previous pathologic studies that failed to detect gastrin-secreting tumors. Incorporated into this investigation was a trial to determine whether the combination of oxymorphone and acepromazine could be used for acid secretory studies. Compared to pentobarbital, which has been frequently used for acid secretory studies in a research setting, the drug combination resulted in increased gastric fluid volumes, a comparative increase in acid secretion, and a rapid uneventful recovery. We conclude that the combination of oxymorphone and acepromazine provides an acceptable means of restraint in dogs undergoing acid secretory studies.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume5
Issue number1
StatePublished - Jan 1991
Externally publishedYes

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gastric acid
Gastric Acid
digestive system diseases
secretion
Dogs
dogs
gastrins
Enteritis
Gastrins
enteritis
gastritis
Gastritis
Oxymorphone
Acepromazine
secretin
acepromazine
Acids
Secretin
acids
Stomach

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Gastric acid secretion in Basenji dogs with immunoproliferative enteropathy. / Breitschwerdt, E. B.; Maclachlan, Nigel J; Argenzio, R. A.; Hurlbert, S. A.; Babineau, C.; De Buysscher, E. V.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 5, No. 1, 01.1991, p. 34-39.

Research output: Contribution to journalArticle

Breitschwerdt, E. B. ; Maclachlan, Nigel J ; Argenzio, R. A. ; Hurlbert, S. A. ; Babineau, C. ; De Buysscher, E. V. / Gastric acid secretion in Basenji dogs with immunoproliferative enteropathy. In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 1991 ; Vol. 5, No. 1. pp. 34-39.
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