Abstract
The gas-phase hydrogen/deuterium (HID) exchange kinetics of several protonated amino acids and dipeptides under a background pressure of CH 3OD were determined in an external source Fourier transform mass spectrometer. H/D exchange reactions occur even when the gas-phase basicity of the compound is significantly larger (> 20 kcal/mol) than methanol. In addition; greater deuterium incorporation is observed for compounds that have multiple sites of similar basicities. A mechanism is proposed that involves a structurally specific intermediate with extensive interaction between the protonated compound and methanol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 623-631 |
| Number of pages | 9 |
| Journal | Journal of the American Society for Mass Spectrometry |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1994 |
ASJC Scopus subject areas
- Spectroscopy
- Structural Biology
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Gard, E., Green, M. K., Bregar, J., & Lebrilla, C. B. (1994). Gas-phase hydrogen/deuterium exchange as a molecular probe for the interaction of methanol and protonated peptides. Journal of the American Society for Mass Spectrometry, 5(7), 623-631. https://doi.org/10.1016/1044-0305(94)85003-8