Abstract
The gas-phase hydrogen/deuterium (HID) exchange kinetics of several protonated amino acids and dipeptides under a background pressure of CH 3OD were determined in an external source Fourier transform mass spectrometer. H/D exchange reactions occur even when the gas-phase basicity of the compound is significantly larger (> 20 kcal/mol) than methanol. In addition; greater deuterium incorporation is observed for compounds that have multiple sites of similar basicities. A mechanism is proposed that involves a structurally specific intermediate with extensive interaction between the protonated compound and methanol.
Original language | English (US) |
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Pages (from-to) | 623-631 |
Number of pages | 9 |
Journal | Journal of the American Society for Mass Spectrometry |
Volume | 5 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1994 |
ASJC Scopus subject areas
- Spectroscopy
- Structural Biology