Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas

Tamer Refaat, Michelle Gentile, Sean Sachdev, Prarthana Dalal, Anish Butala, Stanley Gutiontov, Irene Helenowksi, Plato Lee, Vythialinga Sathiaseelan, Orin Bloch, James Chandler, John A. Kalapurakal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29.79%). Median time to local recurrence was 89 months (mean: 69, range: 47-168). The 3- and 5-year actuarial local control (LC) rates were 68.9 and 55.7%, respectively. The 3- and 5-year overall survival rates were 88.6 and 81.1%, respectively. There was a trend toward worse LC with tumors treated with radiation doses ≤ 13 versus > 13 Gy. There was no radiation necrosis or second malignant tumors noted in our series. Conclusion This report, one of the largest GKRS series for grade 2 meningiomas, demonstrates that GKRS is a safe and effective treatment modality for patients with grade 2 meningiomas with durable tumor control and minimal toxicity. Adjuvant GKRS could be considered as a reasonable treatment approach for patients with grade 2 meningiomas.

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalJournal of Neurological Surgery, Part B: Skull Base
Volume78
Issue number4
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Radiosurgery
Meningioma
Radiation
Recurrence
Neoplasms
Research Ethics Committees
Necrosis
Survival Rate
Therapeutics

Keywords

  • Gamma Knife
  • grade 2
  • meningioma
  • radiosurgery
  • stereotactic

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Refaat, T., Gentile, M., Sachdev, S., Dalal, P., Butala, A., Gutiontov, S., ... Kalapurakal, J. A. (2017). Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas. Journal of Neurological Surgery, Part B: Skull Base, 78(4), 288-294. https://doi.org/10.1055/s-0036-1597834

Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas. / Refaat, Tamer; Gentile, Michelle; Sachdev, Sean; Dalal, Prarthana; Butala, Anish; Gutiontov, Stanley; Helenowksi, Irene; Lee, Plato; Sathiaseelan, Vythialinga; Bloch, Orin; Chandler, James; Kalapurakal, John A.

In: Journal of Neurological Surgery, Part B: Skull Base, Vol. 78, No. 4, 01.08.2017, p. 288-294.

Research output: Contribution to journalArticle

Refaat, T, Gentile, M, Sachdev, S, Dalal, P, Butala, A, Gutiontov, S, Helenowksi, I, Lee, P, Sathiaseelan, V, Bloch, O, Chandler, J & Kalapurakal, JA 2017, 'Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas', Journal of Neurological Surgery, Part B: Skull Base, vol. 78, no. 4, pp. 288-294. https://doi.org/10.1055/s-0036-1597834
Refaat T, Gentile M, Sachdev S, Dalal P, Butala A, Gutiontov S et al. Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas. Journal of Neurological Surgery, Part B: Skull Base. 2017 Aug 1;78(4):288-294. https://doi.org/10.1055/s-0036-1597834
Refaat, Tamer ; Gentile, Michelle ; Sachdev, Sean ; Dalal, Prarthana ; Butala, Anish ; Gutiontov, Stanley ; Helenowksi, Irene ; Lee, Plato ; Sathiaseelan, Vythialinga ; Bloch, Orin ; Chandler, James ; Kalapurakal, John A. / Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas. In: Journal of Neurological Surgery, Part B: Skull Base. 2017 ; Vol. 78, No. 4. pp. 288-294.
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abstract = "Purpose This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29.79{\%}). Median time to local recurrence was 89 months (mean: 69, range: 47-168). The 3- and 5-year actuarial local control (LC) rates were 68.9 and 55.7{\%}, respectively. The 3- and 5-year overall survival rates were 88.6 and 81.1{\%}, respectively. There was a trend toward worse LC with tumors treated with radiation doses ≤ 13 versus > 13 Gy. There was no radiation necrosis or second malignant tumors noted in our series. Conclusion This report, one of the largest GKRS series for grade 2 meningiomas, demonstrates that GKRS is a safe and effective treatment modality for patients with grade 2 meningiomas with durable tumor control and minimal toxicity. Adjuvant GKRS could be considered as a reasonable treatment approach for patients with grade 2 meningiomas.",
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