Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation: The case of zoledronic acid-induced acute phase reaction

M. De Santis, F. Cavaciocchi, A. Ceribelli, C. Crotti, E. Generali, G. Fabbriciani, C. Selmi, M. Massarotti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is observed in chronic inflammation and autoimmunity. In this study we investigated whether the phenotype of γδ T cells is associated with APR and 25-OH vitamin D (25-OHvD) levels. For flow-cytometry analysis, peripheral blood samples were obtained from 52 osteoporotic women prior to 5-mg ZA intravenous infusion and from nine women (five with APR) one week later. Twenty-six/52 (50%) patients reported APR and APR+ cases had a higher percentage of central memory Th1-like γδ T cells. One week after ZA infusion, APR was associated with a decreased percentage of central memory Th1-like γδ T cells, an increase in the percentage and activation of effector memory Th1-like γδ T cells, and an increase in Th17-like γδ T cells. Lower 25-OHvD levels were significantly associated with APR, but no correlation was found between 25-OHvD level and γδ T cell percentage or subsets. In conclusion, patients experiencing APR related to ZA infusion have lower 25-OHvD levels and we suggest that the higher percentage of central memory Th1-like γδ T cells and the expansion of effector memory Th1-like and Th17-like γδ T cells are associated with the occurrence of APR.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalLupus
Volume24
DOIs
StatePublished - Apr 25 2015

Fingerprint

zoledronic acid
Acute-Phase Reaction
Autoimmunity
Vitamin D
Inflammation
T-Lymphocytes

Keywords

  • adverse event
  • bisphosphonate
  • bone loss
  • Osteoporosis
  • zoledronate

ASJC Scopus subject areas

  • Rheumatology

Cite this

Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation : The case of zoledronic acid-induced acute phase reaction. / De Santis, M.; Cavaciocchi, F.; Ceribelli, A.; Crotti, C.; Generali, E.; Fabbriciani, G.; Selmi, C.; Massarotti, M.

In: Lupus, Vol. 24, 25.04.2015, p. 442-447.

Research output: Contribution to journalArticle

De Santis, M, Cavaciocchi, F, Ceribelli, A, Crotti, C, Generali, E, Fabbriciani, G, Selmi, C & Massarotti, M 2015, 'Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation: The case of zoledronic acid-induced acute phase reaction', Lupus, vol. 24, pp. 442-447. https://doi.org/10.1177/0961203314559633
De Santis, M. ; Cavaciocchi, F. ; Ceribelli, A. ; Crotti, C. ; Generali, E. ; Fabbriciani, G. ; Selmi, C. ; Massarotti, M. / Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation : The case of zoledronic acid-induced acute phase reaction. In: Lupus. 2015 ; Vol. 24. pp. 442-447.
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