Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation: The case of zoledronic acid-induced acute phase reaction

M. De Santis, F. Cavaciocchi, A. Ceribelli, C. Crotti, E. Generali, G. Fabbriciani, C. Selmi, M. Massarotti

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is observed in chronic inflammation and autoimmunity. In this study we investigated whether the phenotype of γδ T cells is associated with APR and 25-OH vitamin D (25-OHvD) levels. For flow-cytometry analysis, peripheral blood samples were obtained from 52 osteoporotic women prior to 5-mg ZA intravenous infusion and from nine women (five with APR) one week later. Twenty-six/52 (50%) patients reported APR and APR+ cases had a higher percentage of central memory Th1-like γδ T cells. One week after ZA infusion, APR was associated with a decreased percentage of central memory Th1-like γδ T cells, an increase in the percentage and activation of effector memory Th1-like γδ T cells, and an increase in Th17-like γδ T cells. Lower 25-OHvD levels were significantly associated with APR, but no correlation was found between 25-OHvD level and γδ T cell percentage or subsets. In conclusion, patients experiencing APR related to ZA infusion have lower 25-OHvD levels and we suggest that the higher percentage of central memory Th1-like γδ T cells and the expansion of effector memory Th1-like and Th17-like γδ T cells are associated with the occurrence of APR.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalLupus
Volume24
DOIs
StatePublished - Apr 25 2015

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Keywords

  • adverse event
  • bisphosphonate
  • bone loss
  • Osteoporosis
  • zoledronate

ASJC Scopus subject areas

  • Rheumatology

Cite this

De Santis, M., Cavaciocchi, F., Ceribelli, A., Crotti, C., Generali, E., Fabbriciani, G., Selmi, C., & Massarotti, M. (2015). Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation: The case of zoledronic acid-induced acute phase reaction. Lupus, 24, 442-447. https://doi.org/10.1177/0961203314559633