Abstract
Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is observed in chronic inflammation and autoimmunity. In this study we investigated whether the phenotype of γδ T cells is associated with APR and 25-OH vitamin D (25-OHvD) levels. For flow-cytometry analysis, peripheral blood samples were obtained from 52 osteoporotic women prior to 5-mg ZA intravenous infusion and from nine women (five with APR) one week later. Twenty-six/52 (50%) patients reported APR and APR+ cases had a higher percentage of central memory Th1-like γδ T cells. One week after ZA infusion, APR was associated with a decreased percentage of central memory Th1-like γδ T cells, an increase in the percentage and activation of effector memory Th1-like γδ T cells, and an increase in Th17-like γδ T cells. Lower 25-OHvD levels were significantly associated with APR, but no correlation was found between 25-OHvD level and γδ T cell percentage or subsets. In conclusion, patients experiencing APR related to ZA infusion have lower 25-OHvD levels and we suggest that the higher percentage of central memory Th1-like γδ T cells and the expansion of effector memory Th1-like and Th17-like γδ T cells are associated with the occurrence of APR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 442-447 |
| Number of pages | 6 |
| Journal | Lupus |
| Volume | 24 |
| DOIs | |
| State | Published - Apr 25 2015 |
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Keywords
- adverse event
- bisphosphonate
- bone loss
- Osteoporosis
- zoledronate
ASJC Scopus subject areas
- Rheumatology
Cite this
Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation : The case of zoledronic acid-induced acute phase reaction. / De Santis, M.; Cavaciocchi, F.; Ceribelli, A.; Crotti, C.; Generali, E.; Fabbriciani, G.; Selmi, C.; Massarotti, M.
In: Lupus, Vol. 24, 25.04.2015, p. 442-447.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation
T2 - The case of zoledronic acid-induced acute phase reaction
AU - De Santis, M.
AU - Cavaciocchi, F.
AU - Ceribelli, A.
AU - Crotti, C.
AU - Generali, E.
AU - Fabbriciani, G.
AU - Selmi, C.
AU - Massarotti, M.
PY - 2015/4/25
Y1 - 2015/4/25
N2 - Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is observed in chronic inflammation and autoimmunity. In this study we investigated whether the phenotype of γδ T cells is associated with APR and 25-OH vitamin D (25-OHvD) levels. For flow-cytometry analysis, peripheral blood samples were obtained from 52 osteoporotic women prior to 5-mg ZA intravenous infusion and from nine women (five with APR) one week later. Twenty-six/52 (50%) patients reported APR and APR+ cases had a higher percentage of central memory Th1-like γδ T cells. One week after ZA infusion, APR was associated with a decreased percentage of central memory Th1-like γδ T cells, an increase in the percentage and activation of effector memory Th1-like γδ T cells, and an increase in Th17-like γδ T cells. Lower 25-OHvD levels were significantly associated with APR, but no correlation was found between 25-OHvD level and γδ T cell percentage or subsets. In conclusion, patients experiencing APR related to ZA infusion have lower 25-OHvD levels and we suggest that the higher percentage of central memory Th1-like γδ T cells and the expansion of effector memory Th1-like and Th17-like γδ T cells are associated with the occurrence of APR.
AB - Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is observed in chronic inflammation and autoimmunity. In this study we investigated whether the phenotype of γδ T cells is associated with APR and 25-OH vitamin D (25-OHvD) levels. For flow-cytometry analysis, peripheral blood samples were obtained from 52 osteoporotic women prior to 5-mg ZA intravenous infusion and from nine women (five with APR) one week later. Twenty-six/52 (50%) patients reported APR and APR+ cases had a higher percentage of central memory Th1-like γδ T cells. One week after ZA infusion, APR was associated with a decreased percentage of central memory Th1-like γδ T cells, an increase in the percentage and activation of effector memory Th1-like γδ T cells, and an increase in Th17-like γδ T cells. Lower 25-OHvD levels were significantly associated with APR, but no correlation was found between 25-OHvD level and γδ T cell percentage or subsets. In conclusion, patients experiencing APR related to ZA infusion have lower 25-OHvD levels and we suggest that the higher percentage of central memory Th1-like γδ T cells and the expansion of effector memory Th1-like and Th17-like γδ T cells are associated with the occurrence of APR.
KW - adverse event
KW - bisphosphonate
KW - bone loss
KW - Osteoporosis
KW - zoledronate
UR - http://www.scopus.com/inward/record.url?scp=84925615613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925615613&partnerID=8YFLogxK
U2 - 10.1177/0961203314559633
DO - 10.1177/0961203314559633
M3 - Article
C2 - 25801887
AN - SCOPUS:84925615613
VL - 24
SP - 442
EP - 447
JO - Lupus
JF - Lupus
SN - 0961-2033
ER -