Gall bladder mucoceles and their association with endocrinopathies in dogs: A retrospective case-control study

M. L L Mesich, Philipp Mayhew, M. Paek, D. E. Holt, D. C. Brown

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study. Methods: Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression. Results: The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed. Clinical Significance: Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.

Original languageEnglish (US)
Pages (from-to)630-635
Number of pages6
JournalJournal of Small Animal Practice
Volume50
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Mucocele
gall bladder
case-control studies
Case-Control Studies
Urinary Bladder
Dogs
Adrenocortical Hyperfunction
dogs
hyperadrenocorticism
hypothyroidism
diabetes mellitus
Hypothyroidism
Diabetes Mellitus
Logistic Models
Observation
breeds

ASJC Scopus subject areas

  • Small Animals

Cite this

Gall bladder mucoceles and their association with endocrinopathies in dogs : A retrospective case-control study. / Mesich, M. L L; Mayhew, Philipp; Paek, M.; Holt, D. E.; Brown, D. C.

In: Journal of Small Animal Practice, Vol. 50, No. 12, 12.2009, p. 630-635.

Research output: Contribution to journalArticle

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