Abstract
Objective: To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study. Methods: Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression. Results: The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed. Clinical Significance: Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 630-635 |
| Number of pages | 6 |
| Journal | Journal of Small Animal Practice |
| Volume | 50 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Small Animals
Cite this
Gall bladder mucoceles and their association with endocrinopathies in dogs : A retrospective case-control study. / Mesich, M. L L; Mayhew, Philipp; Paek, M.; Holt, D. E.; Brown, D. C.
In: Journal of Small Animal Practice, Vol. 50, No. 12, 12.2009, p. 630-635.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gall bladder mucoceles and their association with endocrinopathies in dogs
T2 - A retrospective case-control study
AU - Mesich, M. L L
AU - Mayhew, Philipp
AU - Paek, M.
AU - Holt, D. E.
AU - Brown, D. C.
PY - 2009/12
Y1 - 2009/12
N2 - Objective: To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study. Methods: Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression. Results: The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed. Clinical Significance: Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.
AB - Objective: To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study. Methods: Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression. Results: The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed. Clinical Significance: Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.
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UR - http://www.scopus.com/inward/citedby.url?scp=71149093242&partnerID=8YFLogxK
U2 - 10.1111/j.1748-5827.2009.00811.x
DO - 10.1111/j.1748-5827.2009.00811.x
M3 - Article
C2 - 19954439
AN - SCOPUS:71149093242
VL - 50
SP - 630
EP - 635
JO - Journal of Small Animal Practice
JF - Journal of Small Animal Practice
SN - 0022-4510
IS - 12
ER -