Galectins: Structure, function and therapeutic potential

Ri Yao Yang, Gabriel A. Rabinovich, Fu-Tong Liu

Research output: Contribution to journalArticle

433 Citations (Scopus)

Abstract

Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins are also detectable in the cytosol and nucleus, and may influence cellular functions such as intracellular signalling pathways through protein-protein interactions with other cytoplasmic and nuclear proteins. Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair. Some of these have been discovered or confirmed by using genetically engineered mice deficient in a particular galectin. Thus, galectins may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases.

Original languageEnglish (US)
JournalExpert Reviews in Molecular Medicine
Volume10
Issue number17
DOIs
StatePublished - Jun 2008

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Galectins
Therapeutics
Physiological Phenomena
Galactosides
Pathologic Processes
Medical problems
Nuclear Proteins
Lectins
Cytosol
Extracellular Matrix
Polysaccharides
Tumors
Neoplasms
Atherosclerosis
Proteins
Repair
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Molecular Medicine

Cite this

Galectins : Structure, function and therapeutic potential. / Yang, Ri Yao; Rabinovich, Gabriel A.; Liu, Fu-Tong.

In: Expert Reviews in Molecular Medicine, Vol. 10, No. 17, 06.2008.

Research output: Contribution to journalArticle

Yang, Ri Yao ; Rabinovich, Gabriel A. ; Liu, Fu-Tong. / Galectins : Structure, function and therapeutic potential. In: Expert Reviews in Molecular Medicine. 2008 ; Vol. 10, No. 17.
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