Galectins in Apoptosis

Daniel K. Hsu, Ri Yao Yang, Fu-Tong Liu

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Galectins are a family of animal lectins with affinity for β-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively documented function is induction of apoptosis. By using gene transfection approaches, galectins have been shown to regulate various cellular processes, including apoptosis. Evidence has been provided that some of these functions involve binding to cytoplasmic and nuclear proteins, through protein-protein interactions, and modulation of intracellular signaling pathways. Thus, some galectins are pro-apoptotic, whereas others are anti-apoptotic; some galectins induce apoptosis by binding to cell surface glycoproteins, whereas others regulate apoptosis through interactions with intracellular proteins. This review describes involvement of galectin-1, -2, -3, -7, -8, -9, and -12 in apoptosis.

Original languageEnglish (US)
Pages (from-to)256-273
Number of pages18
JournalMethods in Enzymology
Volume417
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Galectins
Apoptosis
Lectins
Galectin 2
Galectin 1
Galactosides
Proteins
Glycoconjugates
Membrane Glycoproteins
Nuclear Proteins
Recombinant Proteins
Extracellular Matrix
Transfection
Genes
Carbohydrates
Modulation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hsu, D. K., Yang, R. Y., & Liu, F-T. (2006). Galectins in Apoptosis. Methods in Enzymology, 417, 256-273. https://doi.org/10.1016/S0076-6879(06)17018-4

Galectins in Apoptosis. / Hsu, Daniel K.; Yang, Ri Yao; Liu, Fu-Tong.

In: Methods in Enzymology, Vol. 417, 2006, p. 256-273.

Research output: Contribution to journalArticle

Hsu, DK, Yang, RY & Liu, F-T 2006, 'Galectins in Apoptosis', Methods in Enzymology, vol. 417, pp. 256-273. https://doi.org/10.1016/S0076-6879(06)17018-4
Hsu, Daniel K. ; Yang, Ri Yao ; Liu, Fu-Tong. / Galectins in Apoptosis. In: Methods in Enzymology. 2006 ; Vol. 417. pp. 256-273.
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