Abstract
Galectins are a family of animal lectins with affinity for β-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively documented function is induction of apoptosis. By using gene transfection approaches, galectins have been shown to regulate various cellular processes, including apoptosis. Evidence has been provided that some of these functions involve binding to cytoplasmic and nuclear proteins, through protein-protein interactions, and modulation of intracellular signaling pathways. Thus, some galectins are pro-apoptotic, whereas others are anti-apoptotic; some galectins induce apoptosis by binding to cell surface glycoproteins, whereas others regulate apoptosis through interactions with intracellular proteins. This review describes involvement of galectin-1, -2, -3, -7, -8, -9, and -12 in apoptosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 256-273 |
| Number of pages | 18 |
| Journal | Methods in Enzymology |
| Volume | 417 |
| DOIs | |
| State | Published - 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Galectins in Apoptosis. / Hsu, Daniel K.; Yang, Ri Yao; Liu, Fu-Tong.
In: Methods in Enzymology, Vol. 417, 2006, p. 256-273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Galectins in Apoptosis
AU - Hsu, Daniel K.
AU - Yang, Ri Yao
AU - Liu, Fu-Tong
PY - 2006
Y1 - 2006
N2 - Galectins are a family of animal lectins with affinity for β-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively documented function is induction of apoptosis. By using gene transfection approaches, galectins have been shown to regulate various cellular processes, including apoptosis. Evidence has been provided that some of these functions involve binding to cytoplasmic and nuclear proteins, through protein-protein interactions, and modulation of intracellular signaling pathways. Thus, some galectins are pro-apoptotic, whereas others are anti-apoptotic; some galectins induce apoptosis by binding to cell surface glycoproteins, whereas others regulate apoptosis through interactions with intracellular proteins. This review describes involvement of galectin-1, -2, -3, -7, -8, -9, and -12 in apoptosis.
AB - Galectins are a family of animal lectins with affinity for β-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively documented function is induction of apoptosis. By using gene transfection approaches, galectins have been shown to regulate various cellular processes, including apoptosis. Evidence has been provided that some of these functions involve binding to cytoplasmic and nuclear proteins, through protein-protein interactions, and modulation of intracellular signaling pathways. Thus, some galectins are pro-apoptotic, whereas others are anti-apoptotic; some galectins induce apoptosis by binding to cell surface glycoproteins, whereas others regulate apoptosis through interactions with intracellular proteins. This review describes involvement of galectin-1, -2, -3, -7, -8, -9, and -12 in apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=33751258005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751258005&partnerID=8YFLogxK
U2 - 10.1016/S0076-6879(06)17018-4
DO - 10.1016/S0076-6879(06)17018-4
M3 - Article
C2 - 17132510
AN - SCOPUS:33751258005
VL - 417
SP - 256
EP - 273
JO - Methods
JF - Methods
SN - 0076-6879
ER -