Galectins as modulators of tumour progression

Fu-Tong Liu, Gabriel A. Rabinovich

Research output: Contribution to journalArticle

998 Scopus citations

Abstract

Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, by interacting with cytoplasmic and nuclear proteins to modulate signalling pathways. Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis. They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology?

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalNature Reviews Cancer
Volume5
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Cancer Research

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