Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response?

Gabriel A. Rabinovich, Linda G. Baum, Nicola Tinari, Roberto Paganelli, Clara Natoli, Fu-Tong Liu, Stefano Iacobelli

Research output: Contribution to journalArticle

449 Scopus citations

Abstract

Recent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for β-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalTrends in Immunology
Volume23
Issue number6
DOIs
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Rabinovich, G. A., Baum, L. G., Tinari, N., Paganelli, R., Natoli, C., Liu, F-T., & Iacobelli, S. (2002). Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response? Trends in Immunology, 23(6), 313-320. https://doi.org/10.1016/S1471-4906(02)02232-9