Abstract
Recent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for β-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-320 |
| Number of pages | 8 |
| Journal | Trends in Immunology |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2002 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Galectins and their ligands : Amplifiers, silencers or tuners of the inflammatory response? / Rabinovich, Gabriel A.; Baum, Linda G.; Tinari, Nicola; Paganelli, Roberto; Natoli, Clara; Liu, Fu-Tong; Iacobelli, Stefano.
In: Trends in Immunology, Vol. 23, No. 6, 01.06.2002, p. 313-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Galectins and their ligands
T2 - Amplifiers, silencers or tuners of the inflammatory response?
AU - Rabinovich, Gabriel A.
AU - Baum, Linda G.
AU - Tinari, Nicola
AU - Paganelli, Roberto
AU - Natoli, Clara
AU - Liu, Fu-Tong
AU - Iacobelli, Stefano
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Recent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for β-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.
AB - Recent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for β-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036606914&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(02)02232-9
DO - 10.1016/S1471-4906(02)02232-9
M3 - Article
C2 - 12072371
AN - SCOPUS:0036606914
VL - 23
SP - 313
EP - 320
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 6
ER -