Galectins and cutaneous immunity

Huan Yuan Chen, Chia Hui Lo, Chi Shan Li, Daniel K. Hsu, Fu-Tong Liu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different functions through extracellular and intracellular actions. Galectins can be involved in the pathogenesis of inflammatory skin diseases by affecting growth, apoptosis, maturation, activation, and motility of keratinocytes and immune cells. Expression of galectins may change depending on the cellular status, such as proliferation and activation. For example, galectin-3 expression is upregulated in T cells but downregulated in dendritic cells when these cells are activated. Furthermore, their expression may also change under pathological conditions. Understanding the function of each galectin in keratinocytes and different immune cell types may reveal how galectins contribute to the pathogenesis of immune-mediated skin diseases.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalDermatologica Sinica
Volume30
Issue number4
DOIs
StatePublished - Dec 2012

Keywords

  • cutaneous immunity
  • galectin
  • inflammation
  • skin disease

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Chen, H. Y., Lo, C. H., Li, C. S., Hsu, D. K., & Liu, F-T. (2012). Galectins and cutaneous immunity. Dermatologica Sinica, 30(4), 121-127. https://doi.org/10.1016/j.dsi.2012.10.002