Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17–IgA Axis

Chih Chia Liang, Chi Shan Li, I. Chun Weng, Huan Yuan Chen, Hsueh Han Lu, Chiu Ching Huang, Fu-Tong Liu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Impairment of the intestinal mucosal immunity significantly increases the risk of acute and chronic diseases. IgA plays a major role in humoral mucosal immunity to provide protection against pathogens and toxins in the gut. Here, we investigated the role of endogenous galectin-9, a tandem repeat-type β-galactoside–binding protein, in intestinal mucosal immunity. By mucosal immunization of Lgals9−/− and littermate control mice, it was found that lack of galectin-9 impaired mucosal antigen-specific IgA response in the gut. Moreover, Lgals9−/− mice were more susceptible to developing watery diarrhea and more prone to death in response to high-dose cholera toxin. The results indicate the importance of galectin-9 in modulating intestinal adaptive immunity. Furthermore, bone marrow chimera mice were established, and galectin-9 in hematopoietic cells was found to be critical for adaptive IgA response. In addition, immunized Lgals9−/− mice exhibited lower expression of Il17 and fewer T helper 17 (Th17) cells in the lamina propria, implying that the Th17–IgA axis is involved in this mechanism. Taken together, these findings suggest that galectin-9 plays a role in mucosal adaptive immunity through the Th17–IgA axis. By manipulating the expression or activity of galectin-9, intestinal mucosal immune response can be altered and may benefit the development of mucosal vaccination.

Original languageEnglish (US)
Pages (from-to)1225-1235
Number of pages11
JournalAmerican Journal of Pathology
Issue number5
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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