Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

Felipe L. Oliveira, Roger Chammas, Lauremília Ricon, Marise L. Fermino, Emerson S. Bernardes, Daniel K. Hsu, Fu-Tong Liu, Radovan Borojevic, Márcia C. El-Cheikh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Extracellular galectin-3 participates in the control of B2 lymphocyte migration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin-3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3-/- mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3-/- mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43-/- and galectin-3-/- mice, but in contrast to CD43-/- mice, the accumulation of B1 cells in peritoneal membranes in galectin-3-/- mice was accompanied by their functional differentiation into plasma cells. We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.

Original languageEnglish (US)
Pages (from-to)1248-1258
Number of pages11
JournalGlycobiology
Volume19
Issue number11
DOIs
StatePublished - 2009

Fingerprint

Galectin 3
Plasma Cells
Lymphocytes
Cell Differentiation
Plasmas
Lymphocyte Count
Adhesion
Membranes
Cell Physiological Phenomena
Mesentery
Peritoneum
Peritoneal Cavity
Physiology
Down-Regulation
Cells

Keywords

  • B1 lymphocytes
  • Galectin-3
  • Peritoneal cavity
  • Plasma cell

ASJC Scopus subject areas

  • Biochemistry

Cite this

Oliveira, F. L., Chammas, R., Ricon, L., Fermino, M. L., Bernardes, E. S., Hsu, D. K., ... El-Cheikh, M. C. (2009). Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. Glycobiology, 19(11), 1248-1258. https://doi.org/10.1093/glycob/cwp120

Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. / Oliveira, Felipe L.; Chammas, Roger; Ricon, Lauremília; Fermino, Marise L.; Bernardes, Emerson S.; Hsu, Daniel K.; Liu, Fu-Tong; Borojevic, Radovan; El-Cheikh, Márcia C.

In: Glycobiology, Vol. 19, No. 11, 2009, p. 1248-1258.

Research output: Contribution to journalArticle

Oliveira, FL, Chammas, R, Ricon, L, Fermino, ML, Bernardes, ES, Hsu, DK, Liu, F-T, Borojevic, R & El-Cheikh, MC 2009, 'Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells', Glycobiology, vol. 19, no. 11, pp. 1248-1258. https://doi.org/10.1093/glycob/cwp120
Oliveira FL, Chammas R, Ricon L, Fermino ML, Bernardes ES, Hsu DK et al. Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. Glycobiology. 2009;19(11):1248-1258. https://doi.org/10.1093/glycob/cwp120
Oliveira, Felipe L. ; Chammas, Roger ; Ricon, Lauremília ; Fermino, Marise L. ; Bernardes, Emerson S. ; Hsu, Daniel K. ; Liu, Fu-Tong ; Borojevic, Radovan ; El-Cheikh, Márcia C. / Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. In: Glycobiology. 2009 ; Vol. 19, No. 11. pp. 1248-1258.
@article{bc14852c90cb4ef79396905f6b6d0223,
title = "Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells",
abstract = "Extracellular galectin-3 participates in the control of B2 lymphocyte migration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin-3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3-/- mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3-/- mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43-/- and galectin-3-/- mice, but in contrast to CD43-/- mice, the accumulation of B1 cells in peritoneal membranes in galectin-3-/- mice was accompanied by their functional differentiation into plasma cells. We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.",
keywords = "B1 lymphocytes, Galectin-3, Peritoneal cavity, Plasma cell",
author = "Oliveira, {Felipe L.} and Roger Chammas and Laurem{\'i}lia Ricon and Fermino, {Marise L.} and Bernardes, {Emerson S.} and Hsu, {Daniel K.} and Fu-Tong Liu and Radovan Borojevic and El-Cheikh, {M{\'a}rcia C.}",
year = "2009",
doi = "10.1093/glycob/cwp120",
language = "English (US)",
volume = "19",
pages = "1248--1258",
journal = "Glycobiology",
issn = "0959-6658",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

AU - Oliveira, Felipe L.

AU - Chammas, Roger

AU - Ricon, Lauremília

AU - Fermino, Marise L.

AU - Bernardes, Emerson S.

AU - Hsu, Daniel K.

AU - Liu, Fu-Tong

AU - Borojevic, Radovan

AU - El-Cheikh, Márcia C.

PY - 2009

Y1 - 2009

N2 - Extracellular galectin-3 participates in the control of B2 lymphocyte migration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin-3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3-/- mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3-/- mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43-/- and galectin-3-/- mice, but in contrast to CD43-/- mice, the accumulation of B1 cells in peritoneal membranes in galectin-3-/- mice was accompanied by their functional differentiation into plasma cells. We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.

AB - Extracellular galectin-3 participates in the control of B2 lymphocyte migration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin-3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3-/- mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3-/- mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43-/- and galectin-3-/- mice, but in contrast to CD43-/- mice, the accumulation of B1 cells in peritoneal membranes in galectin-3-/- mice was accompanied by their functional differentiation into plasma cells. We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.

KW - B1 lymphocytes

KW - Galectin-3

KW - Peritoneal cavity

KW - Plasma cell

UR - http://www.scopus.com/inward/record.url?scp=70349982083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349982083&partnerID=8YFLogxK

U2 - 10.1093/glycob/cwp120

DO - 10.1093/glycob/cwp120

M3 - Article

VL - 19

SP - 1248

EP - 1258

JO - Glycobiology

JF - Glycobiology

SN - 0959-6658

IS - 11

ER -