Galectin-3 is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution

Jörg Mengwasser, Fu-Tong Liu, Jonathan P. Sleeman

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Galectin-3 is an endogenous mammalian lectin that binds to ABH carbohydrate antigens. Here we show that galectin-3 is strongly up-regulated during mammary gland involution and that it is expressed virtually exclusively on nonapoptotic cells. We demonstrate that dexamethasone, an inhibitor of the second phase of mammary gland involution, potently suppresses up-regulation of galectin-3 as judged immunohistochemically and on western blots, suggesting that systemic hormone levels regulate galectin-3 expression during involution. However, at the RNA level galectin-3 expression is rapidly up-regulated on the onset of involution but remains consistantly high during the first and second phase of involution regardless of dexamethasone treatment. These data suggest that the up-regulation of galectin-3 in the involuting mammary gland is not only controlled transcriptionally but also regulated posttranscriptionally under the control of systemic glucocorticoid hormones involved in coordinating the involution process.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalGlycobiology
Volume12
Issue number2
StatePublished - 2002

Keywords

  • ABH histo-blood group antigen
  • Apoptosis
  • Galectin-3
  • Mammary gland
  • Tissue remodeling

ASJC Scopus subject areas

  • Biochemistry

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