Galectin-3 induces death of Candida species expressing specific β-1,2-linked mannans

Luciana Kohatsu, Daniel K. Hsu, Armin G. Jegalian, Fu-Tong Liu, Linda G. Baum

Research output: Contribution to journalArticlepeer-review

171 Scopus citations


Lectins play a critical role in host protection against infection. The galectin family of lectins recognizes saccharide ligands on a variety of microbial pathogens, including viruses, bacteria, and parasites. Galectin-3, a galectin expressed by macrophages, dendritic cells, and epithelial cells, binds bacterial and parasitic pathogens including Leishmania major, Trypanosoma cruzi, and Neisseria gonorrhoeae. However, there have been no reports of galectins having sited effects on microbial viability. We found that galectin-3 bound only to Candida albicans species that bear β-1,2-linked oligomannans on the cell surface, but did not bind Saccharomyces ceravisias that lacks β-1,2-linked oligomannans. Surprisingly, binding directly induced death of Candida species containing specific β-1,2-linked oligomannosides. Thus, galectin-3 can act as a pattern recognition receptor that recognizes a unique pathogen-specific oligosaccharide sequence. This is the first description of antimicrobial activity for a member of the galectin family of mammalian lectins; unlike other lectins of the innate immune system that promote opsonization and phagocytosis, galectin-3 has direct fungicidal activity against opportunistic fungal pathogens.

Original languageEnglish (US)
Pages (from-to)4718-4726
Number of pages9
JournalJournal of Immunology
Issue number7
StatePublished - Oct 1 2006

ASJC Scopus subject areas

  • Immunology


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