Galectin-3, a β-galactoside-binding animal lectin, is a marker of anaplastic large-cell lymphoma

Konstantin N. Konstantinov, Bruce A. Robbins, Fu-Tong Liu

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Galectin-3 is a member of a newly named family of β-galactoside-binding animal lectins, which has been described with a number of possible important biological functions, including the regulation of cell growth and association with tumor transformation. This protein has a wide tissue distribution but is notably not expressed by normal lymphocytes. We have previously shown that galectin-3 is markedly up-regulated in HTLV-1-infected T cells, most likely mediated by the viral transactivating protein Tax. In this study, we surveyed various lymphomas by immunohistochemistry and found the expression of galectin-3 in all of the 8 cases of Ki-1 + anaplastic large-cell lymphoma (ALCL). Immunoreactivity for galectin-3 was found in a majority of the neoplastic cells in the ALCLs studied. In contrast, only 2 of the 35 cases of other types of lymphoma, including various Hodgkin's and non-Hodgkin's lymphomas, were positive. Unlike the cases of ALCL, immunoreactivity for galectin-3 in these 3 cases was found only sporadically in a small number of neoplastic cells. Thus, galectin-3 may prove to be a useful marker for ALCL and its expression in neoplastic cells in ALCL may contribute to the biological behavior of this specific type of lymphoma.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalAmerican Journal of Pathology
Volume148
Issue number1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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