Galanin impairs performance on learning and memory tasks: Findings from galanin transgenic and GAL-R1 knockout mice

Nathan R. Rustay, Craige C. Wrenn, Jefferson W. Kinney, Andrew Holmes, Kathleen R. Bailey, Timothy L. Sullivan, Ashley P. Harris, Katharine C. Long, Maria C. Saavedra, Grzegorz Starosta, Caitlin E. Innerfield, Rebecca J. Yang, Jennifer L. Dreiling, Jacqueline Crawley

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats. GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe trial of the Morris water maze spatial learning task, on the social transmission of food preference olfactory memory task, and on the trace cued fear conditioning emotional learning and memory task. Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning, suggesting a selective role for the GAL-R1 in aversive memories, and implicating other GAL receptor subtypes in spatial learning and olfactory social memory. The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalNeuropeptides
Volume39
Issue number3
DOIs
StatePublished - Jun 2005
Externally publishedYes

Fingerprint

Galanin
Knockout Mice
Learning
Data storage equipment
Galanin Receptors
Fear
Maze Learning
Food Preferences
Transgenic Mice
Rodentia
Alzheimer Disease
Rats
Water

Keywords

  • Alzheimers disease
  • Fear conditioning
  • Galanin
  • Learning
  • Memory
  • Peptide overexpression
  • Receptor subtypes
  • Transgenic mice

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

Cite this

Galanin impairs performance on learning and memory tasks : Findings from galanin transgenic and GAL-R1 knockout mice. / Rustay, Nathan R.; Wrenn, Craige C.; Kinney, Jefferson W.; Holmes, Andrew; Bailey, Kathleen R.; Sullivan, Timothy L.; Harris, Ashley P.; Long, Katharine C.; Saavedra, Maria C.; Starosta, Grzegorz; Innerfield, Caitlin E.; Yang, Rebecca J.; Dreiling, Jennifer L.; Crawley, Jacqueline.

In: Neuropeptides, Vol. 39, No. 3, 06.2005, p. 239-243.

Research output: Contribution to journalArticle

Rustay, NR, Wrenn, CC, Kinney, JW, Holmes, A, Bailey, KR, Sullivan, TL, Harris, AP, Long, KC, Saavedra, MC, Starosta, G, Innerfield, CE, Yang, RJ, Dreiling, JL & Crawley, J 2005, 'Galanin impairs performance on learning and memory tasks: Findings from galanin transgenic and GAL-R1 knockout mice', Neuropeptides, vol. 39, no. 3, pp. 239-243. https://doi.org/10.1016/j.npep.2004.12.026
Rustay, Nathan R. ; Wrenn, Craige C. ; Kinney, Jefferson W. ; Holmes, Andrew ; Bailey, Kathleen R. ; Sullivan, Timothy L. ; Harris, Ashley P. ; Long, Katharine C. ; Saavedra, Maria C. ; Starosta, Grzegorz ; Innerfield, Caitlin E. ; Yang, Rebecca J. ; Dreiling, Jennifer L. ; Crawley, Jacqueline. / Galanin impairs performance on learning and memory tasks : Findings from galanin transgenic and GAL-R1 knockout mice. In: Neuropeptides. 2005 ; Vol. 39, No. 3. pp. 239-243.
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