Galanin impairs performance on learning and memory tasks: Findings from galanin transgenic and GAL-R1 knockout mice

Nathan R. Rustay, Craige C. Wrenn, Jefferson W. Kinney, Andrew Holmes, Kathleen R. Bailey, Timothy L. Sullivan, Ashley P. Harris, Katharine C. Long, Maria C. Saavedra, Grzegorz Starosta, Caitlin E. Innerfield, Rebecca J. Yang, Jennifer L. Dreiling, Jacqueline Crawley

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats. GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe trial of the Morris water maze spatial learning task, on the social transmission of food preference olfactory memory task, and on the trace cued fear conditioning emotional learning and memory task. Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning, suggesting a selective role for the GAL-R1 in aversive memories, and implicating other GAL receptor subtypes in spatial learning and olfactory social memory. The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalNeuropeptides
Volume39
Issue number3
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Alzheimers disease
  • Fear conditioning
  • Galanin
  • Learning
  • Memory
  • Peptide overexpression
  • Receptor subtypes
  • Transgenic mice

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

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  • Cite this

    Rustay, N. R., Wrenn, C. C., Kinney, J. W., Holmes, A., Bailey, K. R., Sullivan, T. L., Harris, A. P., Long, K. C., Saavedra, M. C., Starosta, G., Innerfield, C. E., Yang, R. J., Dreiling, J. L., & Crawley, J. (2005). Galanin impairs performance on learning and memory tasks: Findings from galanin transgenic and GAL-R1 knockout mice. Neuropeptides, 39(3), 239-243. https://doi.org/10.1016/j.npep.2004.12.026