Abstract
The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1836-1841 |
| Number of pages | 6 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 65 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
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Keywords
- Alzheimer's
- Fear conditioning
- Learning and memory
- Morris water maze
- Receptor knockout mice
- Social transmission of food preference
- Transgenic mice
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology