Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Research output: Contribution to journalArticle

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Abstract

The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

Original languageEnglish (US)
Pages (from-to)1836-1841
Number of pages6
JournalCellular and Molecular Life Sciences
Volume65
Issue number12
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Keywords

  • Alzheimer's
  • Fear conditioning
  • Learning and memory
  • Morris water maze
  • Receptor knockout mice
  • Social transmission of food preference
  • Transgenic mice

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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