Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Jacqueline Crawley

doi:10.1007/s00018-008-8158-3

Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Jacqueline Crawley

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

Original language	English (US)
Pages (from-to)	1836-1841
Number of pages	6
Journal	Cellular and Molecular Life Sciences
Volume	65
Issue number	12
DOIs	https://doi.org/10.1007/s00018-008-8158-3
State	Published - Jun 2008
Externally published	Yes

Keywords

Alzheimer's
Fear conditioning
Learning and memory
Morris water maze
Receptor knockout mice
Social transmission of food preference
Transgenic mice

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

Access to Document

10.1007/s00018-008-8158-3

Fingerprint Dive into the research topics of 'Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease'. Together they form a unique fingerprint.

Cite this

Crawley, J. (2008). Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease. Cellular and Molecular Life Sciences, 65(12), 1836-1841. https://doi.org/10.1007/s00018-008-8158-3

@article{74bc54cd956a473497acc9fc9fd5eef0,

title = "Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease",

abstract = "The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).",

keywords = "Alzheimer's, Fear conditioning, Learning and memory, Morris water maze, Receptor knockout mice, Social transmission of food preference, Transgenic mice",

author = "Jacqueline Crawley",

year = "2008",

month = jun,

doi = "10.1007/s00018-008-8158-3",

language = "English (US)",

volume = "65",

pages = "1836--1841",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

number = "12",

}

TY - JOUR

T1 - Galanin impairs cognitive abilities in rodents

T2 - Relevance to Alzheimer's disease

AU - Crawley, Jacqueline

PY - 2008/6

Y1 - 2008/6

N2 - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

AB - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

KW - Alzheimer's

KW - Fear conditioning

KW - Learning and memory

KW - Morris water maze

KW - Receptor knockout mice

KW - Social transmission of food preference

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=45849128307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45849128307&partnerID=8YFLogxK

U2 - 10.1007/s00018-008-8158-3

DO - 10.1007/s00018-008-8158-3

M3 - Article

C2 - 18500642

AN - SCOPUS:45849128307

VL - 65

SP - 1836

EP - 1841

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 12

ER -