Abstract
The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1836-1841 |
| Number of pages | 6 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 65 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
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Keywords
- Alzheimer's
- Fear conditioning
- Learning and memory
- Morris water maze
- Receptor knockout mice
- Social transmission of food preference
- Transgenic mice
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
Galanin impairs cognitive abilities in rodents : Relevance to Alzheimer's disease. / Crawley, Jacqueline.
In: Cellular and Molecular Life Sciences, Vol. 65, No. 12, 06.2008, p. 1836-1841.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Galanin impairs cognitive abilities in rodents
T2 - Relevance to Alzheimer's disease
AU - Crawley, Jacqueline
PY - 2008/6
Y1 - 2008/6
N2 - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).
AB - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).
KW - Alzheimer's
KW - Fear conditioning
KW - Learning and memory
KW - Morris water maze
KW - Receptor knockout mice
KW - Social transmission of food preference
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=45849128307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849128307&partnerID=8YFLogxK
U2 - 10.1007/s00018-008-8158-3
DO - 10.1007/s00018-008-8158-3
M3 - Article
C2 - 18500642
AN - SCOPUS:45849128307
VL - 65
SP - 1836
EP - 1841
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 12
ER -