Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Jacqueline Crawley

doi:10.1007/s00018-008-8158-3

Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

Original language	English (US)
Pages (from-to)	1836-1841
Number of pages	6
Journal	Cellular and Molecular Life Sciences
Volume	65
Issue number	12
DOIs	https://doi.org/10.1007/s00018-008-8158-3
State	Published - Jun 2008
Externally published	Yes

Keywords

Alzheimer's
Fear conditioning
Learning and memory
Morris water maze
Receptor knockout mice
Social transmission of food preference
Transgenic mice

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

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abstract = "The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).",

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AB - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. (Part of a Multi-author Review).

KW - Alzheimer's

KW - Fear conditioning

KW - Learning and memory

KW - Morris water maze

KW - Receptor knockout mice

KW - Social transmission of food preference

KW - Transgenic mice

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Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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