TY - JOUR
T1 - Galanin impairs cognitive abilities in rodents
T2 - relevance to Alzheimer's disease.
AU - Crawley, Jacqueline
PY - 2010
Y1 - 2010
N2 - The neuropeptide galanin and its receptors are localized in brain pathways that mediate learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the fact that overexpression of galanin occurs in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in patients suffering from Alzheimer's.
AB - The neuropeptide galanin and its receptors are localized in brain pathways that mediate learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the fact that overexpression of galanin occurs in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in patients suffering from Alzheimer's.
UR - http://www.scopus.com/inward/record.url?scp=79952258151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952258151&partnerID=8YFLogxK
U2 - 10.1007/978-3-0346-0228-0_10
DO - 10.1007/978-3-0346-0228-0_10
M3 - Article
C2 - 21299066
AN - SCOPUS:79952258151
VL - 102
SP - 133
EP - 141
JO - Experientia. Supplementum
JF - Experientia. Supplementum
SN - 1023-294X
ER -