Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat

R. L. Corwin, J. K. Robinson, Jacqueline Crawley

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

Galanin significantly increased food intake when microinjected into the region of the central nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In the amygdala this effect was specific to feeding; no change in grooming, resting, or other behaviour was observed after galanin treatment. These results provide evidence that the amygdala may be an important site in the mediation of galanin-nduced feeding. The galanin receptor antagonists, C7 and M40, antagonized galanin-induced feeding, while having no effect alone on food consumption in free-feeding rats. These new galanin receptor antagonists provide useful tools for further investigating the role of endogenous galanin in the regulation of feeding.

Original languageEnglish (US)
Pages (from-to)1528-1533
Number of pages6
JournalEuropean Journal of Neuroscience
Volume5
Issue number11
DOIs
StatePublished - 1993
Externally publishedYes

    Fingerprint

Keywords

  • Antagonists
  • Central nucleus of the amygdala
  • Food consumption
  • Neuropeptide
  • Paraventricular nucleus of the hypothalamus
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this