Galanin and Receptors

K. R. Bailey, Jacqueline Crawley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Its N-terminal amino acid sequence is highly conserved across species. Three G-protein-coupled galanin receptors have been identified, with discrete localizations consistent with the anatomical distribution of galanin-immunoreactive neurons and terminal fields. Biological actions of galanin are generally inhibitory, including attenuation of the release of glutamate, acetylcholine, and serotonin; inhibition of signal transduction through adenylate cyclase; and reduced long-term potentiation. Experiments using exogenous administration of galanin and targeted mutation of the galanin gene and galanin receptor subtypes genes provide evidence that galanin blocks seizures, impairs performance on learning and memory tasks, produces anxiolytic-like and depression-related effects, increases feeding, inhibits insulin release from the pancreas, promotes peripheral axonal regeneration, and reduces pain transmission in peripheral nerves.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages491-498
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Alzheimer's
  • Anxiety
  • Cardiovascular
  • Diabetes
  • Feeding
  • Galanin
  • Gastrointestinal
  • Glutamate
  • Learning
  • Memory
  • Neuroanatomy
  • Neuropeptide
  • Neuroregeneration
  • Neurotransmitter release
  • Pain
  • Receptor
  • Seizures
  • Serotonin
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Galanin and Receptors'. Together they form a unique fingerprint.

  • Cite this

    Bailey, K. R., & Crawley, J. (2010). Galanin and Receptors. In Encyclopedia of Neuroscience (pp. 491-498). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01441-8