Galanin and Receptors

K. R. Bailey, Jacqueline Crawley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Its N-terminal amino acid sequence is highly conserved across species. Three G-protein-coupled galanin receptors have been identified, with discrete localizations consistent with the anatomical distribution of galanin-immunoreactive neurons and terminal fields. Biological actions of galanin are generally inhibitory, including attenuation of the release of glutamate, acetylcholine, and serotonin; inhibition of signal transduction through adenylate cyclase; and reduced long-term potentiation. Experiments using exogenous administration of galanin and targeted mutation of the galanin gene and galanin receptor subtypes genes provide evidence that galanin blocks seizures, impairs performance on learning and memory tasks, produces anxiolytic-like and depression-related effects, increases feeding, inhibits insulin release from the pancreas, promotes peripheral axonal regeneration, and reduces pain transmission in peripheral nerves.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages491-498
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Galanin Receptors
Galanin
Long-Term Potentiation
Anti-Anxiety Agents
Peripheral Nervous System
G-Protein-Coupled Receptors
Neuropeptides
Peripheral Nerves
Adenylyl Cyclases
Genes
Acetylcholine
Regeneration
Glutamic Acid
Pancreas
Amino Acid Sequence
Signal Transduction
Serotonin
Seizures
Central Nervous System
Learning

Keywords

  • Alzheimer's
  • Anxiety
  • Cardiovascular
  • Diabetes
  • Feeding
  • Galanin
  • Gastrointestinal
  • Glutamate
  • Learning
  • Memory
  • Neuroanatomy
  • Neuropeptide
  • Neuroregeneration
  • Neurotransmitter release
  • Pain
  • Receptor
  • Seizures
  • Serotonin
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bailey, K. R., & Crawley, J. (2010). Galanin and Receptors. In Encyclopedia of Neuroscience (pp. 491-498). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01441-8

Galanin and Receptors. / Bailey, K. R.; Crawley, Jacqueline.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 491-498.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bailey, KR & Crawley, J 2010, Galanin and Receptors. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 491-498. https://doi.org/10.1016/B978-008045046-9.01441-8
Bailey KR, Crawley J. Galanin and Receptors. In Encyclopedia of Neuroscience. Elsevier Ltd. 2010. p. 491-498 https://doi.org/10.1016/B978-008045046-9.01441-8
Bailey, K. R. ; Crawley, Jacqueline. / Galanin and Receptors. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 491-498
@inbook{a2e88703acff4b14b246c871280fd9ae,
title = "Galanin and Receptors",
abstract = "Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Its N-terminal amino acid sequence is highly conserved across species. Three G-protein-coupled galanin receptors have been identified, with discrete localizations consistent with the anatomical distribution of galanin-immunoreactive neurons and terminal fields. Biological actions of galanin are generally inhibitory, including attenuation of the release of glutamate, acetylcholine, and serotonin; inhibition of signal transduction through adenylate cyclase; and reduced long-term potentiation. Experiments using exogenous administration of galanin and targeted mutation of the galanin gene and galanin receptor subtypes genes provide evidence that galanin blocks seizures, impairs performance on learning and memory tasks, produces anxiolytic-like and depression-related effects, increases feeding, inhibits insulin release from the pancreas, promotes peripheral axonal regeneration, and reduces pain transmission in peripheral nerves.",
keywords = "Alzheimer's, Anxiety, Cardiovascular, Diabetes, Feeding, Galanin, Gastrointestinal, Glutamate, Learning, Memory, Neuroanatomy, Neuropeptide, Neuroregeneration, Neurotransmitter release, Pain, Receptor, Seizures, Serotonin, Signal transduction",
author = "Bailey, {K. R.} and Jacqueline Crawley",
year = "2010",
doi = "10.1016/B978-008045046-9.01441-8",
language = "English (US)",
isbn = "9780080450469",
pages = "491--498",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Galanin and Receptors

AU - Bailey, K. R.

AU - Crawley, Jacqueline

PY - 2010

Y1 - 2010

N2 - Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Its N-terminal amino acid sequence is highly conserved across species. Three G-protein-coupled galanin receptors have been identified, with discrete localizations consistent with the anatomical distribution of galanin-immunoreactive neurons and terminal fields. Biological actions of galanin are generally inhibitory, including attenuation of the release of glutamate, acetylcholine, and serotonin; inhibition of signal transduction through adenylate cyclase; and reduced long-term potentiation. Experiments using exogenous administration of galanin and targeted mutation of the galanin gene and galanin receptor subtypes genes provide evidence that galanin blocks seizures, impairs performance on learning and memory tasks, produces anxiolytic-like and depression-related effects, increases feeding, inhibits insulin release from the pancreas, promotes peripheral axonal regeneration, and reduces pain transmission in peripheral nerves.

AB - Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Its N-terminal amino acid sequence is highly conserved across species. Three G-protein-coupled galanin receptors have been identified, with discrete localizations consistent with the anatomical distribution of galanin-immunoreactive neurons and terminal fields. Biological actions of galanin are generally inhibitory, including attenuation of the release of glutamate, acetylcholine, and serotonin; inhibition of signal transduction through adenylate cyclase; and reduced long-term potentiation. Experiments using exogenous administration of galanin and targeted mutation of the galanin gene and galanin receptor subtypes genes provide evidence that galanin blocks seizures, impairs performance on learning and memory tasks, produces anxiolytic-like and depression-related effects, increases feeding, inhibits insulin release from the pancreas, promotes peripheral axonal regeneration, and reduces pain transmission in peripheral nerves.

KW - Alzheimer's

KW - Anxiety

KW - Cardiovascular

KW - Diabetes

KW - Feeding

KW - Galanin

KW - Gastrointestinal

KW - Glutamate

KW - Learning

KW - Memory

KW - Neuroanatomy

KW - Neuropeptide

KW - Neuroregeneration

KW - Neurotransmitter release

KW - Pain

KW - Receptor

KW - Seizures

KW - Serotonin

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=84882890477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882890477&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.01441-8

DO - 10.1016/B978-008045046-9.01441-8

M3 - Chapter

SN - 9780080450469

SP - 491

EP - 498

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -