Galanin-acetylcholine interactions: Relevance to memory and Alzheimer's disease

Jacqueline Crawley

doi:10.1016/0024-3205(96)00093-8

Galanin-acetylcholine interactions: Relevance to memory and Alzheimer's disease

Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain and its projection areas in mammalian brain. Centrally administered galanin inhibits acetylcholine release in the rat ventral hippocampus, and produces deficits in learning and memory tasks. In Alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of Meynert cell bodies. Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias.

Original language	English (US)
Pages (from-to)	2185-2199
Number of pages	15
Journal	Life Sciences
Volume	58
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(96)00093-8
State	Published - May 10 1996
Externally published	Yes

Keywords

Acetylcholine
Alzheimer's disease
Galanin
Learning and memory
Neuropeptide
Neurotransmitter release

ASJC Scopus subject areas

Pharmacology

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AB - The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain and its projection areas in mammalian brain. Centrally administered galanin inhibits acetylcholine release in the rat ventral hippocampus, and produces deficits in learning and memory tasks. In Alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of Meynert cell bodies. Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias.

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