Galanin-acetylcholine interactions: Relevance to memory and Alzheimer's disease

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain and its projection areas in mammalian brain. Centrally administered galanin inhibits acetylcholine release in the rat ventral hippocampus, and produces deficits in learning and memory tasks. In Alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of Meynert cell bodies. Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias.

Original languageEnglish (US)
Pages (from-to)2185-2199
Number of pages15
JournalLife Sciences
Volume58
Issue number24
DOIs
StatePublished - May 10 1996
Externally publishedYes

Keywords

  • Acetylcholine
  • Alzheimer's disease
  • Galanin
  • Learning and memory
  • Neuropeptide
  • Neurotransmitter release

ASJC Scopus subject areas

  • Pharmacology

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