Gains in body fat and vasomotor symptom reporting over the menopausal transition

Rebecca C. Thurston, Maryfran R. Sowers, Barbara Sternfeld, Ellen B Gold, Joyce Bromberger, Yuefang Chang, Hadine Joffe, Carolyn J. Crandall, L Elaine Waetjen, Karen A. Matthews

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with vasomotor symptoms cross-sectionally, but the longitudinal relation between changes in body fat and vasomotor symptoms is uncharacterized. The study aim was to examine whether gains in body fat were related to vasomotor symptom reporting over time. Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47-59 years participating in the Study of Women's Health Across the Nation. Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations. Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status (relative to stable body fat, gain: odds ratio=1.23, 95% confidence interval: 1.02, 1.48; P=0.03; loss: odds ratio=1.07, 95% confidence interval: 0.89, 1.29; P=0.45). Findings persisted controlling for estradiol, the free estradiol index, or follicle-stimulating hormone concentrations. The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition.

Original languageEnglish (US)
Pages (from-to)766-774
Number of pages9
JournalAmerican Journal of Epidemiology
Volume170
Issue number6
DOIs
StatePublished - Sep 2009

Fingerprint

Adipose Tissue
Hot Flashes
Sweat
Estradiol
Odds Ratio
Confidence Intervals
Follicle Stimulating Hormone
Women's Health
Parity
Electric Impedance
Anxiety
Smoking
Hormones
Education

Keywords

  • Adipose tissue
  • Adiposity
  • Body composition
  • Body fat distribution
  • Climacteric
  • Hot flashes
  • Menopause

ASJC Scopus subject areas

  • Epidemiology

Cite this

Thurston, R. C., Sowers, M. R., Sternfeld, B., Gold, E. B., Bromberger, J., Chang, Y., ... Matthews, K. A. (2009). Gains in body fat and vasomotor symptom reporting over the menopausal transition. American Journal of Epidemiology, 170(6), 766-774. https://doi.org/10.1093/aje/kwp203

Gains in body fat and vasomotor symptom reporting over the menopausal transition. / Thurston, Rebecca C.; Sowers, Maryfran R.; Sternfeld, Barbara; Gold, Ellen B; Bromberger, Joyce; Chang, Yuefang; Joffe, Hadine; Crandall, Carolyn J.; Waetjen, L Elaine; Matthews, Karen A.

In: American Journal of Epidemiology, Vol. 170, No. 6, 09.2009, p. 766-774.

Research output: Contribution to journalArticle

Thurston, RC, Sowers, MR, Sternfeld, B, Gold, EB, Bromberger, J, Chang, Y, Joffe, H, Crandall, CJ, Waetjen, LE & Matthews, KA 2009, 'Gains in body fat and vasomotor symptom reporting over the menopausal transition', American Journal of Epidemiology, vol. 170, no. 6, pp. 766-774. https://doi.org/10.1093/aje/kwp203
Thurston, Rebecca C. ; Sowers, Maryfran R. ; Sternfeld, Barbara ; Gold, Ellen B ; Bromberger, Joyce ; Chang, Yuefang ; Joffe, Hadine ; Crandall, Carolyn J. ; Waetjen, L Elaine ; Matthews, Karen A. / Gains in body fat and vasomotor symptom reporting over the menopausal transition. In: American Journal of Epidemiology. 2009 ; Vol. 170, No. 6. pp. 766-774.
@article{70ca20789ccd4da4ad210d72b515ef21,
title = "Gains in body fat and vasomotor symptom reporting over the menopausal transition",
abstract = "Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with vasomotor symptoms cross-sectionally, but the longitudinal relation between changes in body fat and vasomotor symptoms is uncharacterized. The study aim was to examine whether gains in body fat were related to vasomotor symptom reporting over time. Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47-59 years participating in the Study of Women's Health Across the Nation. Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations. Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status (relative to stable body fat, gain: odds ratio=1.23, 95{\%} confidence interval: 1.02, 1.48; P=0.03; loss: odds ratio=1.07, 95{\%} confidence interval: 0.89, 1.29; P=0.45). Findings persisted controlling for estradiol, the free estradiol index, or follicle-stimulating hormone concentrations. The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition.",
keywords = "Adipose tissue, Adiposity, Body composition, Body fat distribution, Climacteric, Hot flashes, Menopause",
author = "Thurston, {Rebecca C.} and Sowers, {Maryfran R.} and Barbara Sternfeld and Gold, {Ellen B} and Joyce Bromberger and Yuefang Chang and Hadine Joffe and Crandall, {Carolyn J.} and Waetjen, {L Elaine} and Matthews, {Karen A.}",
year = "2009",
month = "9",
doi = "10.1093/aje/kwp203",
language = "English (US)",
volume = "170",
pages = "766--774",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Gains in body fat and vasomotor symptom reporting over the menopausal transition

AU - Thurston, Rebecca C.

AU - Sowers, Maryfran R.

AU - Sternfeld, Barbara

AU - Gold, Ellen B

AU - Bromberger, Joyce

AU - Chang, Yuefang

AU - Joffe, Hadine

AU - Crandall, Carolyn J.

AU - Waetjen, L Elaine

AU - Matthews, Karen A.

PY - 2009/9

Y1 - 2009/9

N2 - Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with vasomotor symptoms cross-sectionally, but the longitudinal relation between changes in body fat and vasomotor symptoms is uncharacterized. The study aim was to examine whether gains in body fat were related to vasomotor symptom reporting over time. Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47-59 years participating in the Study of Women's Health Across the Nation. Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations. Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status (relative to stable body fat, gain: odds ratio=1.23, 95% confidence interval: 1.02, 1.48; P=0.03; loss: odds ratio=1.07, 95% confidence interval: 0.89, 1.29; P=0.45). Findings persisted controlling for estradiol, the free estradiol index, or follicle-stimulating hormone concentrations. The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition.

AB - Although most women report vasomotor symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletely understood. Body fat is positively associated with vasomotor symptoms cross-sectionally, but the longitudinal relation between changes in body fat and vasomotor symptoms is uncharacterized. The study aim was to examine whether gains in body fat were related to vasomotor symptom reporting over time. Measures of bioelectrical impedance for body fat, reproductive hormones, and reported vasomotor symptoms were assessed annually over 4 years from 2002 to 2006 among 1,659 women aged 47-59 years participating in the Study of Women's Health Across the Nation. Body fat change was examined in relation to vasomotor symptoms by using generalized estimating equations. Body fat gains were associated with greater odds of reporting hot flashes in models adjusted for age, site, race/ethnicity, education, smoking, parity, anxiety, and menopausal status (relative to stable body fat, gain: odds ratio=1.23, 95% confidence interval: 1.02, 1.48; P=0.03; loss: odds ratio=1.07, 95% confidence interval: 0.89, 1.29; P=0.45). Findings persisted controlling for estradiol, the free estradiol index, or follicle-stimulating hormone concentrations. The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition.

KW - Adipose tissue

KW - Adiposity

KW - Body composition

KW - Body fat distribution

KW - Climacteric

KW - Hot flashes

KW - Menopause

UR - http://www.scopus.com/inward/record.url?scp=69949150208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949150208&partnerID=8YFLogxK

U2 - 10.1093/aje/kwp203

DO - 10.1093/aje/kwp203

M3 - Article

C2 - 19675142

AN - SCOPUS:69949150208

VL - 170

SP - 766

EP - 774

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -