Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys

José Manuel Lozano Reina, David Favre, Zeljka Kasakow, Véronique Mayau, Marie Thérèse Nugeyre, Thierno Ka, Abdourahmane Faye, Chris J Miller, Daniel Scott-Algara, Joseph M. McCune, Françoise Barré-Sinoussi, Ousmane M. Diop, Michaela C. Müller-Trutwin

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.

Original languageEnglish (US)
Pages (from-to)2770-2777
Number of pages8
JournalJournal of Virology
Volume83
Issue number6
DOIs
StatePublished - Mar 2009

ASJC Scopus subject areas

  • Immunology
  • Virology

Fingerprint Dive into the research topics of 'Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys'. Together they form a unique fingerprint.

  • Cite this

    Reina, J. M. L., Favre, D., Kasakow, Z., Mayau, V., Nugeyre, M. T., Ka, T., Faye, A., Miller, C. J., Scott-Algara, D., McCune, J. M., Barré-Sinoussi, F., Diop, O. M., & Müller-Trutwin, M. C. (2009). Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. Journal of Virology, 83(6), 2770-2777. https://doi.org/10.1128/JVI.01841-08