Abstract
Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2770-2777 |
| Number of pages | 8 |
| Journal | Journal of Virology |
| Volume | 83 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 2009 |
ASJC Scopus subject areas
- Immunology
- Virology
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Reina, J. M. L., Favre, D., Kasakow, Z., Mayau, V., Nugeyre, M. T., Ka, T., Faye, A., Miller, C. J., Scott-Algara, D., McCune, J. M., Barré-Sinoussi, F., Diop, O. M., & Müller-Trutwin, M. C. (2009). Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. Journal of Virology, 83(6), 2770-2777. https://doi.org/10.1128/JVI.01841-08