Abstract
Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2770-2777 |
| Number of pages | 8 |
| Journal | Journal of Virology |
| Volume | 83 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 2009 |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. / Reina, José Manuel Lozano; Favre, David; Kasakow, Zeljka; Mayau, Véronique; Nugeyre, Marie Thérèse; Ka, Thierno; Faye, Abdourahmane; Miller, Chris J; Scott-Algara, Daniel; McCune, Joseph M.; Barré-Sinoussi, Françoise; Diop, Ousmane M.; Müller-Trutwin, Michaela C.
In: Journal of Virology, Vol. 83, No. 6, 03.2009, p. 2770-2777.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys
AU - Reina, José Manuel Lozano
AU - Favre, David
AU - Kasakow, Zeljka
AU - Mayau, Véronique
AU - Nugeyre, Marie Thérèse
AU - Ka, Thierno
AU - Faye, Abdourahmane
AU - Miller, Chris J
AU - Scott-Algara, Daniel
AU - McCune, Joseph M.
AU - Barré-Sinoussi, Françoise
AU - Diop, Ousmane M.
AU - Müller-Trutwin, Michaela C.
PY - 2009/3
Y1 - 2009/3
N2 - Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
AB - Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
UR - http://www.scopus.com/inward/record.url?scp=62749107947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62749107947&partnerID=8YFLogxK
U2 - 10.1128/JVI.01841-08
DO - 10.1128/JVI.01841-08
M3 - Article
C2 - 19109377
AN - SCOPUS:62749107947
VL - 83
SP - 2770
EP - 2777
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 6
ER -