Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys

José Manuel Lozano Reina, David Favre, Zeljka Kasakow, Véronique Mayau, Marie Thérèse Nugeyre, Thierno Ka, Abdourahmane Faye, Chris J Miller, Daniel Scott-Algara, Joseph M. McCune, Françoise Barré-Sinoussi, Ousmane M. Diop, Michaela C. Müller-Trutwin

Research output: Contribution to journalArticle

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Abstract

Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 + and CD8 + T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.

Original languageEnglish (US)
Pages (from-to)2770-2777
Number of pages8
JournalJournal of Virology
Volume83
Issue number6
DOIs
StatePublished - Mar 2009

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Simian immunodeficiency virus
Cercopithecus aethiops
Simian Immunodeficiency Virus
B-lymphocytes
T-lymphocytes
T-Lymphocytes
antibodies
Virus Diseases
Antibody Formation
lymph nodes
Anti-Idiotypic Antibodies
Lymph Nodes
antigens
Antigens
blood
infection

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Reina, J. M. L., Favre, D., Kasakow, Z., Mayau, V., Nugeyre, M. T., Ka, T., ... Müller-Trutwin, M. C. (2009). Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. Journal of Virology, 83(6), 2770-2777. https://doi.org/10.1128/JVI.01841-08

Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. / Reina, José Manuel Lozano; Favre, David; Kasakow, Zeljka; Mayau, Véronique; Nugeyre, Marie Thérèse; Ka, Thierno; Faye, Abdourahmane; Miller, Chris J; Scott-Algara, Daniel; McCune, Joseph M.; Barré-Sinoussi, Françoise; Diop, Ousmane M.; Müller-Trutwin, Michaela C.

In: Journal of Virology, Vol. 83, No. 6, 03.2009, p. 2770-2777.

Research output: Contribution to journalArticle

Reina, JML, Favre, D, Kasakow, Z, Mayau, V, Nugeyre, MT, Ka, T, Faye, A, Miller, CJ, Scott-Algara, D, McCune, JM, Barré-Sinoussi, F, Diop, OM & Müller-Trutwin, MC 2009, 'Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys', Journal of Virology, vol. 83, no. 6, pp. 2770-2777. https://doi.org/10.1128/JVI.01841-08
Reina, José Manuel Lozano ; Favre, David ; Kasakow, Zeljka ; Mayau, Véronique ; Nugeyre, Marie Thérèse ; Ka, Thierno ; Faye, Abdourahmane ; Miller, Chris J ; Scott-Algara, Daniel ; McCune, Joseph M. ; Barré-Sinoussi, Françoise ; Diop, Ousmane M. ; Müller-Trutwin, Michaela C. / Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys. In: Journal of Virology. 2009 ; Vol. 83, No. 6. pp. 2770-2777.
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