Gadolinium-enhanced T1-weighted renal and abdominal MR imaging: Quantitative discrepancy between clinical and in vitro findings

Richard W Katzberg, Marija Ivanovic, Michael H. Buonocore, Claire Pellot-Barakat, John M. Brock, John M. Ryan, Kevin Whang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rationale and Objectives. This study was conducted to compare the magnetic resonance (MR) contrast medium enhancement of abdominal organs in vivo with the signal intensity (SI) values of known in vitro gadolinium solutions. Materials and Methods. A phantom was imaged with the MR contrast medium gadodiamide (Omniscan; Nycomed, Princeton, NJ) of solutions at full-strength (0.5 mmol/mL), one-third, 1/10, and 1/100 concentrations. A fat-suppressed fast spoiled gradient-echo pulse sequence with flip angles ranging from 10° to 170° (at 20° increments) was performed with a 1.5-T magnet. In 12 subjects, the SIs of abdominal organs were determined with identical imaging parameters, before and after administration of gadodiamide injection at 0.1 mmol/kg. Results. As anticipated, the plot of SI in relation to gadodiamide concentration is nonlinear, with a decrease in SI due to T2 effects at concentrations above 0.05 mmol/mL. The kidney showed the highest SI after gadodiamide enhancement (125.2 ± 11.6 [standard error] at 2.5 minutes), followed by the liver (76.5 ± 11.5 at 1 minute) and spleen (57.26 ± 9.35 at 30 seconds). The SI of the renal medulla (114.2 ± 9.8 at 4.5 minutes) was approximately one-third that in phantom observations. Conclusion. The authors observed a marked discrepancy between empirical contrast medium performance in abdominal organs and SI values for comparable gadodiamide concentrations in vitro. One possible reason is the intracellular compartmentalization of water molecules in vivo. These results suggest a need for a better understanding of MR contrast medium performance in vivo.

Original languageEnglish (US)
Pages (from-to)679-687
Number of pages9
JournalAcademic Radiology
Volume9
Issue number6
DOIs
StatePublished - 2002

Fingerprint

gadodiamide
Gadolinium
Magnetic Resonance Imaging
Kidney
Contrast Media
Magnetic Resonance Spectroscopy
Magnets
In Vitro Techniques
Spleen
Fats

Keywords

  • Abdomen, MR
  • Gadolinium
  • Kidney, MR
  • Magnetic resonance (MR), contrast enhancement
  • Magnetic resonance (MR), experimental

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Katzberg, R. W., Ivanovic, M., Buonocore, M. H., Pellot-Barakat, C., Brock, J. M., Ryan, J. M., & Whang, K. (2002). Gadolinium-enhanced T1-weighted renal and abdominal MR imaging: Quantitative discrepancy between clinical and in vitro findings. Academic Radiology, 9(6), 679-687. https://doi.org/10.1016/S1076-6332(03)80313-6

Gadolinium-enhanced T1-weighted renal and abdominal MR imaging : Quantitative discrepancy between clinical and in vitro findings. / Katzberg, Richard W; Ivanovic, Marija; Buonocore, Michael H.; Pellot-Barakat, Claire; Brock, John M.; Ryan, John M.; Whang, Kevin.

In: Academic Radiology, Vol. 9, No. 6, 2002, p. 679-687.

Research output: Contribution to journalArticle

Katzberg, RW, Ivanovic, M, Buonocore, MH, Pellot-Barakat, C, Brock, JM, Ryan, JM & Whang, K 2002, 'Gadolinium-enhanced T1-weighted renal and abdominal MR imaging: Quantitative discrepancy between clinical and in vitro findings', Academic Radiology, vol. 9, no. 6, pp. 679-687. https://doi.org/10.1016/S1076-6332(03)80313-6
Katzberg, Richard W ; Ivanovic, Marija ; Buonocore, Michael H. ; Pellot-Barakat, Claire ; Brock, John M. ; Ryan, John M. ; Whang, Kevin. / Gadolinium-enhanced T1-weighted renal and abdominal MR imaging : Quantitative discrepancy between clinical and in vitro findings. In: Academic Radiology. 2002 ; Vol. 9, No. 6. pp. 679-687.
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T2 - Quantitative discrepancy between clinical and in vitro findings

AU - Katzberg, Richard W

AU - Ivanovic, Marija

AU - Buonocore, Michael H.

AU - Pellot-Barakat, Claire

AU - Brock, John M.

AU - Ryan, John M.

AU - Whang, Kevin

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N2 - Rationale and Objectives. This study was conducted to compare the magnetic resonance (MR) contrast medium enhancement of abdominal organs in vivo with the signal intensity (SI) values of known in vitro gadolinium solutions. Materials and Methods. A phantom was imaged with the MR contrast medium gadodiamide (Omniscan; Nycomed, Princeton, NJ) of solutions at full-strength (0.5 mmol/mL), one-third, 1/10, and 1/100 concentrations. A fat-suppressed fast spoiled gradient-echo pulse sequence with flip angles ranging from 10° to 170° (at 20° increments) was performed with a 1.5-T magnet. In 12 subjects, the SIs of abdominal organs were determined with identical imaging parameters, before and after administration of gadodiamide injection at 0.1 mmol/kg. Results. As anticipated, the plot of SI in relation to gadodiamide concentration is nonlinear, with a decrease in SI due to T2 effects at concentrations above 0.05 mmol/mL. The kidney showed the highest SI after gadodiamide enhancement (125.2 ± 11.6 [standard error] at 2.5 minutes), followed by the liver (76.5 ± 11.5 at 1 minute) and spleen (57.26 ± 9.35 at 30 seconds). The SI of the renal medulla (114.2 ± 9.8 at 4.5 minutes) was approximately one-third that in phantom observations. Conclusion. The authors observed a marked discrepancy between empirical contrast medium performance in abdominal organs and SI values for comparable gadodiamide concentrations in vitro. One possible reason is the intracellular compartmentalization of water molecules in vivo. These results suggest a need for a better understanding of MR contrast medium performance in vivo.

AB - Rationale and Objectives. This study was conducted to compare the magnetic resonance (MR) contrast medium enhancement of abdominal organs in vivo with the signal intensity (SI) values of known in vitro gadolinium solutions. Materials and Methods. A phantom was imaged with the MR contrast medium gadodiamide (Omniscan; Nycomed, Princeton, NJ) of solutions at full-strength (0.5 mmol/mL), one-third, 1/10, and 1/100 concentrations. A fat-suppressed fast spoiled gradient-echo pulse sequence with flip angles ranging from 10° to 170° (at 20° increments) was performed with a 1.5-T magnet. In 12 subjects, the SIs of abdominal organs were determined with identical imaging parameters, before and after administration of gadodiamide injection at 0.1 mmol/kg. Results. As anticipated, the plot of SI in relation to gadodiamide concentration is nonlinear, with a decrease in SI due to T2 effects at concentrations above 0.05 mmol/mL. The kidney showed the highest SI after gadodiamide enhancement (125.2 ± 11.6 [standard error] at 2.5 minutes), followed by the liver (76.5 ± 11.5 at 1 minute) and spleen (57.26 ± 9.35 at 30 seconds). The SI of the renal medulla (114.2 ± 9.8 at 4.5 minutes) was approximately one-third that in phantom observations. Conclusion. The authors observed a marked discrepancy between empirical contrast medium performance in abdominal organs and SI values for comparable gadodiamide concentrations in vitro. One possible reason is the intracellular compartmentalization of water molecules in vivo. These results suggest a need for a better understanding of MR contrast medium performance in vivo.

KW - Abdomen, MR

KW - Gadolinium

KW - Kidney, MR

KW - Magnetic resonance (MR), contrast enhancement

KW - Magnetic resonance (MR), experimental

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