Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits

Zina Novak, Amy S. Thurmond, Penny L. Ross, Marla K. Jones, Kent L. Thornburg, Richard W Katzberg

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

RATIONALE AND OBJECTIVES. The authors assessed to what extent the commonly used the magnetic resonance imaging contrast agent, gadopentetate dimeglumine, crosses the placenta. METHODS. Eight pregnant rabbits in the third trimester were injected with 0.1 mmol/kg of gadopentetate dimeglumine, and killed 5, 15, 30, or 60 minutes after injection. Placental and fetal tissues were analyzed for gadolinium content. RESULTS. Placental concentrations of gadolinium were initially high (16.6 ± 3.4 micrograms/gram) and then declined with a biexponential pattern. Initial gadolinium levels in the fetal organs were low and remained so except for the fetal kidneys, which showed increased levels of gadolinium from 4.3 ± 1.1 micrograms/gram at 5 minutes to 6.8 ± 1.8 micrograms/gram at 60 minutes. CONCLUSIONS. The results indicate that gadolinium does cross the rabbit placenta, and that concentrations in the placenta and the fetal urinary tract are sufficient for imaging as well as possible fetal toxicity.

Original languageEnglish (US)
Pages (from-to)828-830
Number of pages3
JournalInvestigative Radiology
Volume28
Issue number9
StatePublished - 1993

Fingerprint

Gadolinium DTPA
Gadolinium
Fetus
Rabbits
Placenta
Third Pregnancy Trimester
Urinary Tract
Contrast Media
Magnetic Resonance Imaging
Kidney
Injections

Keywords

  • Fetus
  • Gadolinium
  • Placenta
  • Rabbit

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Novak, Z., Thurmond, A. S., Ross, P. L., Jones, M. K., Thornburg, K. L., & Katzberg, R. W. (1993). Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. Investigative Radiology, 28(9), 828-830.

Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. / Novak, Zina; Thurmond, Amy S.; Ross, Penny L.; Jones, Marla K.; Thornburg, Kent L.; Katzberg, Richard W.

In: Investigative Radiology, Vol. 28, No. 9, 1993, p. 828-830.

Research output: Contribution to journalArticle

Novak, Z, Thurmond, AS, Ross, PL, Jones, MK, Thornburg, KL & Katzberg, RW 1993, 'Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits', Investigative Radiology, vol. 28, no. 9, pp. 828-830.
Novak Z, Thurmond AS, Ross PL, Jones MK, Thornburg KL, Katzberg RW. Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. Investigative Radiology. 1993;28(9):828-830.
Novak, Zina ; Thurmond, Amy S. ; Ross, Penny L. ; Jones, Marla K. ; Thornburg, Kent L. ; Katzberg, Richard W. / Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. In: Investigative Radiology. 1993 ; Vol. 28, No. 9. pp. 828-830.
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AB - RATIONALE AND OBJECTIVES. The authors assessed to what extent the commonly used the magnetic resonance imaging contrast agent, gadopentetate dimeglumine, crosses the placenta. METHODS. Eight pregnant rabbits in the third trimester were injected with 0.1 mmol/kg of gadopentetate dimeglumine, and killed 5, 15, 30, or 60 minutes after injection. Placental and fetal tissues were analyzed for gadolinium content. RESULTS. Placental concentrations of gadolinium were initially high (16.6 ± 3.4 micrograms/gram) and then declined with a biexponential pattern. Initial gadolinium levels in the fetal organs were low and remained so except for the fetal kidneys, which showed increased levels of gadolinium from 4.3 ± 1.1 micrograms/gram at 5 minutes to 6.8 ± 1.8 micrograms/gram at 60 minutes. CONCLUSIONS. The results indicate that gadolinium does cross the rabbit placenta, and that concentrations in the placenta and the fetal urinary tract are sufficient for imaging as well as possible fetal toxicity.

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