Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration

Jonathan R Young, I. Orosz, M. A. Franke, H. J. Kim, D. Woodworth, B. M. Ellingson, N. Salamon, W. B. Pope

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. Materials and methods: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. Results: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). Conclusion: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.

Original languageEnglish (US)
JournalClinical Radiology
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Cerebellar Nuclei
Gadolinium
Contrast Media
Pons
Pediatrics
Brain
Health Insurance Portability and Accountability Act
Confounding Factors (Epidemiology)
Research Ethics Committees
Retrospective Studies
Magnetic Resonance Imaging
Radiation
Drug Therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gadolinium deposition in the paediatric brain : T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration. / Young, Jonathan R; Orosz, I.; Franke, M. A.; Kim, H. J.; Woodworth, D.; Ellingson, B. M.; Salamon, N.; Pope, W. B.

In: Clinical Radiology, 01.01.2017.

Research output: Contribution to journalArticle

@article{3a7177f5ee1b45c9ab465389028d928c,
title = "Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration",
abstract = "Aim: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. Materials and methods: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. Results: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). Conclusion: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.",
author = "Young, {Jonathan R} and I. Orosz and Franke, {M. A.} and Kim, {H. J.} and D. Woodworth and Ellingson, {B. M.} and N. Salamon and Pope, {W. B.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.crad.2017.11.005",
language = "English (US)",
journal = "Clinical Radiology",
issn = "0009-9260",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Gadolinium deposition in the paediatric brain

T2 - T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration

AU - Young, Jonathan R

AU - Orosz, I.

AU - Franke, M. A.

AU - Kim, H. J.

AU - Woodworth, D.

AU - Ellingson, B. M.

AU - Salamon, N.

AU - Pope, W. B.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Aim: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. Materials and methods: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. Results: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). Conclusion: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.

AB - Aim: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. Materials and methods: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. Results: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). Conclusion: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.

UR - http://www.scopus.com/inward/record.url?scp=85036661646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036661646&partnerID=8YFLogxK

U2 - 10.1016/j.crad.2017.11.005

DO - 10.1016/j.crad.2017.11.005

M3 - Article

C2 - 29208312

AN - SCOPUS:85036661646

JO - Clinical Radiology

JF - Clinical Radiology

SN - 0009-9260

ER -