Gadd45 proteins

Relevance to aging, longevity and age-related pathologies

Alexey A. Moskalev, Zeljka McBride, Mikhail V. Shaposhnikov, Ekaterina N. Plyusnina, Alex Zhavoronkov, Arie Budovsky, Robi Tacutu, Vadim E. Fraifeld

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

The Gadd45 proteins have been intensively studied, in view of their important role in key cellular processes. Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by controlling the balance between cell (DNA) repair, eliminating (apoptosis) or preventing the expansion of potentially dangerous cells (cell cycle arrest, cellular senescence), and maintaining the stem cell pool. However, the biogerontological aspects have not thus far received sufficient attention. Here we analyzed the pathways and modes of action by which Gadd45 members are involved in aging, longevity and age-related diseases. Because of their pleiotropic action, a decreased inducibility of Gadd45 members may have far-reaching consequences including genome instability, accumulation of DNA damage, and disorders in cellular homeostasis - all of which may eventually contribute to the aging process and age-related disorders (promotion of tumorigenesis, immune disorders, insulin resistance and reduced responsiveness to stress). Most recently, the dGadd45 gene has been identified as a longevity regulator in Drosophila. Although further wide-scale research is warranted, it is becoming increasingly clear that Gadd45s are highly relevant to aging, age-related diseases (ARDs) and to the control of life span, suggesting them as potential therapeutic targets in ARDs and pro-longevity interventions.

Original languageEnglish (US)
Pages (from-to)51-66
Number of pages16
JournalAgeing Research Reviews
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Pathology
Aging of materials
Genes
Proteins
Genomic Instability
Cell Aging
DNA
Immune System Diseases
Cell Cycle Checkpoints
Stem cells
DNA Repair
DNA Damage
Drosophila
Insulin Resistance
Carcinogenesis
Homeostasis
Repair
Stem Cells
Cells
Insulin

Keywords

  • Age-related diseases
  • Aging
  • Gadd45 genes and proteins
  • Longevity
  • Regulatory networks

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Moskalev, A. A., McBride, Z., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., ... Fraifeld, V. E. (2012). Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Research Reviews, 11(1), 51-66. https://doi.org/10.1016/j.arr.2011.09.003

Gadd45 proteins : Relevance to aging, longevity and age-related pathologies. / Moskalev, Alexey A.; McBride, Zeljka; Shaposhnikov, Mikhail V.; Plyusnina, Ekaterina N.; Zhavoronkov, Alex; Budovsky, Arie; Tacutu, Robi; Fraifeld, Vadim E.

In: Ageing Research Reviews, Vol. 11, No. 1, 01.01.2012, p. 51-66.

Research output: Contribution to journalReview article

Moskalev, AA, McBride, Z, Shaposhnikov, MV, Plyusnina, EN, Zhavoronkov, A, Budovsky, A, Tacutu, R & Fraifeld, VE 2012, 'Gadd45 proteins: Relevance to aging, longevity and age-related pathologies', Ageing Research Reviews, vol. 11, no. 1, pp. 51-66. https://doi.org/10.1016/j.arr.2011.09.003
Moskalev AA, McBride Z, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A et al. Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Research Reviews. 2012 Jan 1;11(1):51-66. https://doi.org/10.1016/j.arr.2011.09.003
Moskalev, Alexey A. ; McBride, Zeljka ; Shaposhnikov, Mikhail V. ; Plyusnina, Ekaterina N. ; Zhavoronkov, Alex ; Budovsky, Arie ; Tacutu, Robi ; Fraifeld, Vadim E. / Gadd45 proteins : Relevance to aging, longevity and age-related pathologies. In: Ageing Research Reviews. 2012 ; Vol. 11, No. 1. pp. 51-66.
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