Future strategies for preventing and treating coronary restenosis

Ehrin J. Armstrong, John C. Messenger

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

While drug-eluting stents have improved outcomes after percutaneous coronary intervention, 4-14% of patients in modern clinical trials still develop symptomatic restenosis. Future strategies for prevention of restenosis include modifications to the stent platform, the drug polymer or drug elution system, biocompatible stent coatings, use of bioresorbable scaffolds, and optimization of local and systemic anti-restenotic agents. Novel approaches to treating restenosis include a number of ongoing trials comparing treatment strategies with currently available drug eluting stents, use of drug coated balloons, and interventional strategies to increase stent expansion. While no single technology is likely to eliminate restenosis, the combination of these prevention and treatment strategies promises to improve the long-term outcomes of percutaneous coronary intervention.

Original languageEnglish (US)
Title of host publicationCoronary Artery Restenosis: Causes, Treatment and Clinical Outcomes
PublisherNova Science Publishers, Inc.
Pages263-283
Number of pages21
ISBN (Electronic)9781633213531
ISBN (Print)9781633213463
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Armstrong, E. J., & Messenger, J. C. (2014). Future strategies for preventing and treating coronary restenosis. In Coronary Artery Restenosis: Causes, Treatment and Clinical Outcomes (pp. 263-283). Nova Science Publishers, Inc..