Future directions in genetic for autoimmune diseases

Pietro Invernizzi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Autoimmune diseases affect cumulatively 5-10% of the general population and are multifactorial in their pathogenesis, with both inherited and environmental components. Although our knowledge of their pathogenesis has become more refined, diagnosis more accurate, and therapy more effective, the reasons for their development and the female preponderance of these diseases are still unknown. One of the most intriguing hypothesis to explain the female preponderance is related to sex chromosomes, as women affected by autoimmune diseases have a higher rate of circulating cells with a single X chromosome. In addition, a number of evidences suggest a role of X chromosome gene dosage in autoimmunity. Based on these findings, sex chromosome defects might be the common trait of the susceptibility to autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalJournal of Autoimmunity
Volume33
Issue number1
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
Autoimmune Diseases
Sex Chromosomes
X-Linked Genes
Gene Dosage
X Chromosome
Autoimmunity
Population
Direction compound
Therapeutics

Keywords

  • Etiopathogenesis
  • Female preponderance
  • Genetic factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Future directions in genetic for autoimmune diseases. / Invernizzi, Pietro.

In: Journal of Autoimmunity, Vol. 33, No. 1, 08.2009, p. 1-2.

Research output: Contribution to journalArticle

Invernizzi, Pietro. / Future directions in genetic for autoimmune diseases. In: Journal of Autoimmunity. 2009 ; Vol. 33, No. 1. pp. 1-2.
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