Abstract
Our theme centers on the complex processes that constitute and regulate the function of the gastric mucosa. Although some investigators promote the critical importance of a given element, such as acid, blood flow, or mucus, it is clear that both gastric secretory function and mucosal defense and repair mechanisms are multifactorial and are regulated by redundant control circuits. While it is true that critical studies can be performed in vivo with intact mucosa, at the same time it is frequently difficult, using these methods, to define the specific cellular elements involved in the regulation of secretion, defense, and repair. We now recognize that ulcer disease does not occur simply when this balance is thrown off. To the contrary, ulcer disease commonly occurs when the normal mucosal mechanisms are perturbed by Helicobacter pylori-associated gastro-duodenitis or nonsteroidal anti-infiammatory drugs. In the absence of such perturbation, the redundancy of the regulatory mechanisms underlying gastric secretion and the multiple lines of defense and healing would render ulcer disease rare indeed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Journal of Gastroenterology |
| Volume | 29 |
| Issue number | SUPPL. 7 |
| DOIs | |
| State | Published - 1994 |
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Keywords
- Cytoprotection
- Gastric mucosal defense
- Ulcer
ASJC Scopus subject areas
- Gastroenterology
Cite this
Future directions for reductionistic research in gastric secretion and defense. / Lloyd, Kevin C K; Soll, A. H.
In: Journal of Gastroenterology, Vol. 29, No. SUPPL. 7, 1994, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Future directions for reductionistic research in gastric secretion and defense
AU - Lloyd, Kevin C K
AU - Soll, A. H.
PY - 1994
Y1 - 1994
N2 - Our theme centers on the complex processes that constitute and regulate the function of the gastric mucosa. Although some investigators promote the critical importance of a given element, such as acid, blood flow, or mucus, it is clear that both gastric secretory function and mucosal defense and repair mechanisms are multifactorial and are regulated by redundant control circuits. While it is true that critical studies can be performed in vivo with intact mucosa, at the same time it is frequently difficult, using these methods, to define the specific cellular elements involved in the regulation of secretion, defense, and repair. We now recognize that ulcer disease does not occur simply when this balance is thrown off. To the contrary, ulcer disease commonly occurs when the normal mucosal mechanisms are perturbed by Helicobacter pylori-associated gastro-duodenitis or nonsteroidal anti-infiammatory drugs. In the absence of such perturbation, the redundancy of the regulatory mechanisms underlying gastric secretion and the multiple lines of defense and healing would render ulcer disease rare indeed.
AB - Our theme centers on the complex processes that constitute and regulate the function of the gastric mucosa. Although some investigators promote the critical importance of a given element, such as acid, blood flow, or mucus, it is clear that both gastric secretory function and mucosal defense and repair mechanisms are multifactorial and are regulated by redundant control circuits. While it is true that critical studies can be performed in vivo with intact mucosa, at the same time it is frequently difficult, using these methods, to define the specific cellular elements involved in the regulation of secretion, defense, and repair. We now recognize that ulcer disease does not occur simply when this balance is thrown off. To the contrary, ulcer disease commonly occurs when the normal mucosal mechanisms are perturbed by Helicobacter pylori-associated gastro-duodenitis or nonsteroidal anti-infiammatory drugs. In the absence of such perturbation, the redundancy of the regulatory mechanisms underlying gastric secretion and the multiple lines of defense and healing would render ulcer disease rare indeed.
KW - Cytoprotection
KW - Gastric mucosal defense
KW - Ulcer
UR - http://www.scopus.com/inward/record.url?scp=0027941205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027941205&partnerID=8YFLogxK
U2 - 10.1007/BF01229065
DO - 10.1007/BF01229065
M3 - Article
VL - 29
SP - 1
EP - 5
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - SUPPL. 7
ER -