Future directions for epilepsy research

M. P. Jacobs, G. D. Fischbach, M. R. Davis, M. A. Dichter, R. Dingledine, D. H. Lowenstein, M. J. Morrell, J. L. Noebels, Michael A Rogawski, S. S. Spencer, W. H. Theodore

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The authors propose that epilepsy research embark on a revitalized effort to move from targeting control of symptoms to strategies for prevention and cure. The recent advances that make this a realistic goal include identification of genes mutated in inherited epilepsy syndromes, molecular characterization of brain networks, better imaging of sites of seizure origin, and developments in seizure prediction by quantitative EEG analysis. Research directions include determination of mechanisms of epilepsy development, identification of genes for common epilepsy syndromes through linkage analysis and gene chip technology, and validation of new models of epilepsy and epileptogenesis. Directions for therapeutics include identification of new molecular targets, focal methods of drug delivery tied to EEG activity, gene and cell therapy, and surgical and nonablative therapies. Integrated approaches, such as coupling imaging with electrophysiology, are central to progress in localizing regions of epilepsy development in people at risk and better seizure prediction and treatment for people with epilepsy.

Original languageEnglish (US)
Pages (from-to)1536-1542
Number of pages7
JournalNeurology
Volume57
Issue number9
StatePublished - Nov 13 2001
Externally publishedYes

Fingerprint

Epilepsy
Research
Seizures
Electroencephalography
Electrophysiology
Cell- and Tissue-Based Therapy
Direction compound
Oligonucleotide Array Sequence Analysis
Genetic Therapy
Genes
Therapeutics
Technology
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jacobs, M. P., Fischbach, G. D., Davis, M. R., Dichter, M. A., Dingledine, R., Lowenstein, D. H., ... Theodore, W. H. (2001). Future directions for epilepsy research. Neurology, 57(9), 1536-1542.

Future directions for epilepsy research. / Jacobs, M. P.; Fischbach, G. D.; Davis, M. R.; Dichter, M. A.; Dingledine, R.; Lowenstein, D. H.; Morrell, M. J.; Noebels, J. L.; Rogawski, Michael A; Spencer, S. S.; Theodore, W. H.

In: Neurology, Vol. 57, No. 9, 13.11.2001, p. 1536-1542.

Research output: Contribution to journalArticle

Jacobs, MP, Fischbach, GD, Davis, MR, Dichter, MA, Dingledine, R, Lowenstein, DH, Morrell, MJ, Noebels, JL, Rogawski, MA, Spencer, SS & Theodore, WH 2001, 'Future directions for epilepsy research', Neurology, vol. 57, no. 9, pp. 1536-1542.
Jacobs MP, Fischbach GD, Davis MR, Dichter MA, Dingledine R, Lowenstein DH et al. Future directions for epilepsy research. Neurology. 2001 Nov 13;57(9):1536-1542.
Jacobs, M. P. ; Fischbach, G. D. ; Davis, M. R. ; Dichter, M. A. ; Dingledine, R. ; Lowenstein, D. H. ; Morrell, M. J. ; Noebels, J. L. ; Rogawski, Michael A ; Spencer, S. S. ; Theodore, W. H. / Future directions for epilepsy research. In: Neurology. 2001 ; Vol. 57, No. 9. pp. 1536-1542.
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