Further evidence for papovavirus as the probable etiology of transmissible lymphoma of Syrian hamsters.

Stephen W Barthold, P. N. Bhatt, E. A. Johnson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The role of hamster papovavirus as the etiology of transmissible lymphoma was investigated under strict conditions that prevented natural exposure to the lymphoma agent. In an initial experiment, 19 hamsters that were exposed naturally to transmissible lymphoma were placed in direct and indirect contact with weanling hamsters from an uninfected source. Lymphoma developed in the original infected hamsters as well as hamsters maintained in direct and indirect contact. In addition, one of the contact hamsters developed cutaneous epitheliomas, containing hamster papovavirus. Epithelioma homogenate was inoculated into primary hamster embryo cultures, in which hamster papovavirus replicated. Second and third passage tissue culture fluid containing hamster papovavirus induced lymphomas in suckling and weanling hamsters. Cell culture fluid from uninoculated embryo cultures was not oncogenic.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalLaboratory animal science Chicago
Volume37
Issue number3
StatePublished - Jun 1987
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this