Further characteristics of hippocampal CA1 cells in vitro

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The effects of intracellular current injection on synaptic potentials and spike initiation were studied in hippocampal CA1 pyramidal cells in the in vitro slice preparation. Measures of cell charging time constant, resistance, and rheobase level were similar to those reported by other investigators working with intact preparations. Studies of spike initiation induced by injection of depolarizing ramp currents gave little evidence for a threshold accomodation in CA1 cells. Small amplitude fast-rising spike potentials occurred spontaneously and in association with synaptic excitation of neurons. It is argued that these potentials reflect active spike generation in the dendrites.

Original languageEnglish (US)
Pages (from-to)53-68
Number of pages16
JournalBrain Research
Volume128
Issue number1
DOIs
StatePublished - Jun 3 1977
Externally publishedYes

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Synaptic Potentials
Architectural Accessibility
Injections
Pyramidal Cells
Dendrites
Action Potentials
Research Personnel
Neurons
In Vitro Techniques

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Further characteristics of hippocampal CA1 cells in vitro. / Schwartzkroin, Philip A.

In: Brain Research, Vol. 128, No. 1, 03.06.1977, p. 53-68.

Research output: Contribution to journalArticle

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