Fungal disease of the nose and sinuses: An updated overview

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Fungal diseases of the nose and sinuses encompasses a diverse spectrum of disease. Clinical manifestations are largely dependent upon the immune status of the host, as, given the ubiquitous nature of these organisms, exposure is unavoidable. Asymptomatic colonization of the nasal passages by fungi warrants no treatment and is common, while allergic fungal rhinosinusitis is challenging and often requires a combined approach of surgical intervention, immunotherapy, and corticosteroid administration. A diagnosis requires a combination of IgE immune reactivity, eosinophilic infiltration, and fungi recovery. Similarly, invasive disease may present only after several months of slowly progressive disease, or in rapid and fulminant fashion in the appropriate host. A differentiation of these overlapping syndromes and the pathophysiologic processes at play, and recommended treatment algorithms, are the focus of this review.

Original languageEnglish (US)
Pages (from-to)152-161
Number of pages10
JournalCurrent Allergy and Asthma Reports
Volume13
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Allergic fungal rhinosinusitis
  • Eosinophilic fungal rhinosinusitis
  • Fungal disease
  • Granulomatous fungal sinusitis
  • Invasive sinusitis
  • Overview
  • Pathophysiology
  • Treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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