Fundamental limits of positron emission mammography

W. W. Moses, J. Qi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We explore the causes of performance limitation in positron emission mammography cameras. We compare two basic camera geometries containing the same volume of 511keV photon detectors, one with a parallel plane geometry and another with a rectangular geometry. We find that both geometries have similar performance for the phantom imaged (in Monte Carlo simulation), even though the solid angle coverage of the rectangular camera is about 50% higher than the parallel plane camera. The reconstruction algorithm used significantly affects the resulting image; iterative methods significantly outperform the commonly used focal plane tomography. Finally, the characteristics of the tumor itself, specifically the absolute amount of radiotracer taken up by the tumor, will significantly affect the imaging performance.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume497
Issue number1
DOIs
StatePublished - Jan 21 2003
Externally publishedYes

Fingerprint

Mammography
Positrons
positrons
Cameras
cameras
Geometry
geometry
Tumors
tumors
Iterative methods
Tomography
Photons
tomography
Detectors
Imaging techniques
causes
detectors
photons
simulation

Keywords

  • Breast cancer
  • Focal plane tomography
  • Iterative reconstruction
  • Nuclear medicine instrumentation
  • Positron emission mammography
  • Positron emission tomography

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

Fundamental limits of positron emission mammography. / Moses, W. W.; Qi, J.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 497, No. 1, 21.01.2003, p. 82-89.

Research output: Contribution to journalArticle

@article{fe128fed032d40cea3f62c209c84ffbd,
title = "Fundamental limits of positron emission mammography",
abstract = "We explore the causes of performance limitation in positron emission mammography cameras. We compare two basic camera geometries containing the same volume of 511keV photon detectors, one with a parallel plane geometry and another with a rectangular geometry. We find that both geometries have similar performance for the phantom imaged (in Monte Carlo simulation), even though the solid angle coverage of the rectangular camera is about 50{\%} higher than the parallel plane camera. The reconstruction algorithm used significantly affects the resulting image; iterative methods significantly outperform the commonly used focal plane tomography. Finally, the characteristics of the tumor itself, specifically the absolute amount of radiotracer taken up by the tumor, will significantly affect the imaging performance.",
keywords = "Breast cancer, Focal plane tomography, Iterative reconstruction, Nuclear medicine instrumentation, Positron emission mammography, Positron emission tomography",
author = "Moses, {W. W.} and J. Qi",
year = "2003",
month = "1",
day = "21",
doi = "10.1016/S0168-9002(02)01895-8",
language = "English (US)",
volume = "497",
pages = "82--89",
journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
issn = "0168-9002",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Fundamental limits of positron emission mammography

AU - Moses, W. W.

AU - Qi, J.

PY - 2003/1/21

Y1 - 2003/1/21

N2 - We explore the causes of performance limitation in positron emission mammography cameras. We compare two basic camera geometries containing the same volume of 511keV photon detectors, one with a parallel plane geometry and another with a rectangular geometry. We find that both geometries have similar performance for the phantom imaged (in Monte Carlo simulation), even though the solid angle coverage of the rectangular camera is about 50% higher than the parallel plane camera. The reconstruction algorithm used significantly affects the resulting image; iterative methods significantly outperform the commonly used focal plane tomography. Finally, the characteristics of the tumor itself, specifically the absolute amount of radiotracer taken up by the tumor, will significantly affect the imaging performance.

AB - We explore the causes of performance limitation in positron emission mammography cameras. We compare two basic camera geometries containing the same volume of 511keV photon detectors, one with a parallel plane geometry and another with a rectangular geometry. We find that both geometries have similar performance for the phantom imaged (in Monte Carlo simulation), even though the solid angle coverage of the rectangular camera is about 50% higher than the parallel plane camera. The reconstruction algorithm used significantly affects the resulting image; iterative methods significantly outperform the commonly used focal plane tomography. Finally, the characteristics of the tumor itself, specifically the absolute amount of radiotracer taken up by the tumor, will significantly affect the imaging performance.

KW - Breast cancer

KW - Focal plane tomography

KW - Iterative reconstruction

KW - Nuclear medicine instrumentation

KW - Positron emission mammography

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0037457856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037457856&partnerID=8YFLogxK

U2 - 10.1016/S0168-9002(02)01895-8

DO - 10.1016/S0168-9002(02)01895-8

M3 - Article

AN - SCOPUS:0037457856

VL - 497

SP - 82

EP - 89

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

SN - 0168-9002

IS - 1

ER -