Abstract
Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.
| Original language | English (US) |
|---|---|
| Article number | 344504 |
| Pages (from-to) | 300-303 |
| Number of pages | 4 |
| Journal | Optica |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 20 2019 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz. / Azimipour, Mehdi; Migacz, Justin V.; Zawadzki, Robert; Werner, John S; Jonnal, Ravi.
In: Optica, Vol. 6, No. 3, 344504, 20.03.2019, p. 300-303.Research output: Contribution to journal › Letter
}
TY - JOUR
T1 - Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz
AU - Azimipour, Mehdi
AU - Migacz, Justin V.
AU - Zawadzki, Robert
AU - Werner, John S
AU - Jonnal, Ravi
PY - 2019/3/20
Y1 - 2019/3/20
N2 - Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.
AB - Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.
UR - http://www.scopus.com/inward/record.url?scp=85065993533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065993533&partnerID=8YFLogxK
U2 - 10.1364/OPTICA.6.000300
DO - 10.1364/OPTICA.6.000300
M3 - Letter
AN - SCOPUS:85065993533
VL - 6
SP - 300
EP - 303
JO - Optica
JF - Optica
SN - 2334-2536
IS - 3
M1 - 344504
ER -