Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz

Mehdi Azimipour; Justin V. Migacz; Robert J. Zawadzki; John S. Werner; Ravi S. Jonnal

doi:10.1364/OPTICA.6.000300

Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz

Mehdi Azimipour, Justin V. Migacz, Robert J. Zawadzki, John S. Werner, Ravi S. Jonnal

Ophthalmology and Vision Science

Research output: Contribution to journal › Letter › peer-review

21 Scopus citations

Abstract

Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.

Original language	English (US)
Article number	344504
Pages (from-to)	300-303
Number of pages	4
Journal	Optica
Volume	6
Issue number	3
DOIs	https://doi.org/10.1364/OPTICA.6.000300
State	Published - Mar 20 2019

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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AU - Azimipour, Mehdi

AU - Migacz, Justin V.

AU - Zawadzki, Robert J.

AU - Werner, John S.

AU - Jonnal, Ravi S.

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AB - Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.

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Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz

Abstract

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