Functional magnetic resonance imaging of internal source monitoring in schizophrenia: Recognition with and without recollection

John D Ragland, Jeffrey N. Valdez, James Loughead, Ruben C. Gur, Raquel E. Gur

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Patients with schizophrenia tend to have impaired source monitoring and intact item recognition, suggesting an over-reliance of familiarity effects. We previously demonstrated that providing patients with a levels-of-processing (LOP) semantic encoding strategy normalized source monitoring. The current blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) study tests the hypothesis that patients will have abnormally increased fronto-temporal activation despite intact performance. fMRI was measured in 13 patients and 13 demographically matched healthy controls during a LOP source monitoring paradigm. SPM2 was used for standard pre-processing and statistical analyses, with a corrected significance threshold of p < .05. Examination of accuracy and speed measures did not reveal any group differences in task performance. Regardless of source retrieval success both groups activated expected prefrontal and parietal regions, with no areas of relatively greater control versus patient activation. In support of the hypothesis, patients showed abnormally increased activation in temporolimbic areas including middle and superior temporal gyrus, thalamus, and parahippocampal gyrus. Activation in these areas was associated with worse positive and negative symptoms, but did not correlate with performance, suggesting inefficient rather than compensatory activation.

Original languageEnglish (US)
Pages (from-to)160-171
Number of pages12
JournalSchizophrenia Research
Volume87
Issue number1-3
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Schizophrenia
Magnetic Resonance Imaging
Patient Participation
Parahippocampal Gyrus
Parietal Lobe
Task Performance and Analysis
Temporal Lobe
Thalamus
Semantics
Recognition (Psychology)
Oxygen

Keywords

  • Episodic memory
  • Functional magnetic resonance imaging
  • Schizophrenia
  • Source memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Functional magnetic resonance imaging of internal source monitoring in schizophrenia : Recognition with and without recollection. / Ragland, John D; Valdez, Jeffrey N.; Loughead, James; Gur, Ruben C.; Gur, Raquel E.

In: Schizophrenia Research, Vol. 87, No. 1-3, 10.2006, p. 160-171.

Research output: Contribution to journalArticle

Ragland, John D ; Valdez, Jeffrey N. ; Loughead, James ; Gur, Ruben C. ; Gur, Raquel E. / Functional magnetic resonance imaging of internal source monitoring in schizophrenia : Recognition with and without recollection. In: Schizophrenia Research. 2006 ; Vol. 87, No. 1-3. pp. 160-171.
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