Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma

S. C. Helfand, J. F. Modiano, Peter F Moore, S. A. Soergel, P. S. MacWilliams, R. D. Dubielzig, J. A. Hank, E. W. Gelfand, P. M. Sondel

Research output: Contribution to journalArticle

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Abstract

We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL- 2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.

Original languageEnglish (US)
Pages (from-to)636-645
Number of pages10
JournalBlood
Volume86
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Interleukin-2 Receptors
Interleukin-2
Lymphoma
Dogs
Skin
Lymphocytes
Natural Killer Cells
Large Granular Lymphocytic Leukemia
Lymphokine-Activated Killer Cells
Lymphokines
Hematologic Neoplasms
Signal Transduction
Animals
Blood
Animal Models
Growth
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Helfand, S. C., Modiano, J. F., Moore, P. F., Soergel, S. A., MacWilliams, P. S., Dubielzig, R. D., ... Sondel, P. M. (1995). Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. Blood, 86(2), 636-645.

Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. / Helfand, S. C.; Modiano, J. F.; Moore, Peter F; Soergel, S. A.; MacWilliams, P. S.; Dubielzig, R. D.; Hank, J. A.; Gelfand, E. W.; Sondel, P. M.

In: Blood, Vol. 86, No. 2, 1995, p. 636-645.

Research output: Contribution to journalArticle

Helfand, SC, Modiano, JF, Moore, PF, Soergel, SA, MacWilliams, PS, Dubielzig, RD, Hank, JA, Gelfand, EW & Sondel, PM 1995, 'Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma', Blood, vol. 86, no. 2, pp. 636-645.
Helfand SC, Modiano JF, Moore PF, Soergel SA, MacWilliams PS, Dubielzig RD et al. Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. Blood. 1995;86(2):636-645.
Helfand, S. C. ; Modiano, J. F. ; Moore, Peter F ; Soergel, S. A. ; MacWilliams, P. S. ; Dubielzig, R. D. ; Hank, J. A. ; Gelfand, E. W. ; Sondel, P. M. / Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. In: Blood. 1995 ; Vol. 86, No. 2. pp. 636-645.
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