Functional imaging, the frontal lobes, and dementia

R. P. Friedland, E. Koss, A. Lerner, P. Hedera, W. Ellis, Nina Dronkers, B. A. Ober, W. J. Jagust

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A 58-year-old man developed progressive difficulty with comprehension and verbal output with dementia. Positron emission tomography with 18F 2-fluoro-2-deoxy-D-glucose demonstrated asymmetrical frontal and anterior temporal lobe loss of glucose use. Scopolamine infusion (0.3 mg) did not influence memory. Postmortem studies revealed evidence of Pick's disease, with Pick bodies, loss of somatostatin, preservation of choline acetyltransferase and immunostaining with neurofilament antibodies. Pharmacological challenge and positron imaging offer valuable means for the noninvasive assessment of dementing illness. The contributions of functional imaging to our knowledge of frontal involvement in dementing illness are reviewed.

Original languageEnglish (US)
Pages (from-to)192-203
Number of pages12
Issue number3-4
StatePublished - 1993
Externally publishedYes


  • Dementia
  • Echolalia
  • Frontal lobe demnentia
  • Pick's disease
  • Positron emission tomography
  • Scopolamine

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuropsychology and Physiological Psychology


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