Functional evidence linking potassium channels afferent nerve-mediated mucosal protection in stomach

Fumihiro Iwata, Anthony Koo, Makoto Itoh, Kan Lam, Joseph Leung, Felix W. Leung

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Adenosine triphosphate-dependent potassium (K+ATP) channels in several types of vascular smooth muscles mediate the vasodilation induced by calcitonin gene-related peptide (CGRP). Upon stimulation, primary afferent nerve terminals in the gastric mucosa release CGRP which mediates a protective hyperemia. We tested the hypothesis that a potassium channel blocker aggravates gastric mucosal injury by impairing afferent nerve-mediated hyperemia in the gastric mucosa. Rats were treated with K+ATP channel blocker, glybenclamide (20 mg/kg intravenously). Intragastric acidified ethanol (0.15 N HCl, 15% ethanol) and intragastric capsaicin (160 μM) were also administered. Glybenclamide aggravated the acidified ethanol-induced mucosal injury, and attenuated the mucosal hyperemia (hydrogen gas clearance) induced by intragastric acidified ethanol and intragastric capsaicin. These findings suggest for the first time that K+ATP channels modulate primary afferent nerve-mediated mucosal defense mechanisms in the gastric mucosa.

Original languageEnglish (US)
Pages (from-to)1713-1720
Number of pages8
JournalLife Sciences
Volume61
Issue number17
DOIs
StatePublished - Sep 19 1997

Keywords

  • Afferent nerve-mediated hyperemia
  • Hydrogen gas clearance
  • Potassium channels
  • Tetraethylammonium

ASJC Scopus subject areas

  • Pharmacology

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