Abstract
Communication between a cell surface peptide hormone receptor and an intracellular steroid hormone receptor can take various routes, as dictated by the physiology of a particular cell type. There is increasing evidence for a novel route which requires that a peptide hormone receptor pathway converge on a steroid hormone receptor, leading to its activation. One consequence of such a process can be signal amplification for the peptide hormone receptor agonist. This is exemplified by the self-potentiating action of GnRH, which is a critical component in events leading to a surge in LH secretion and ovulation. One signaling pathway stimulated by the GnRH receptor may entail a phosphorylation cascade resulting in progesterone-independent modulation of progesterone receptor activity.
Original language | English (US) |
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Pages (from-to) | 360-365 |
Number of pages | 6 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 3 |
Issue number | 10 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism