Functional cross-talk between receptors for peptide and steroid hormones

Judith L Turgeon, Dennis W. Waring

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Communication between a cell surface peptide hormone receptor and an intracellular steroid hormone receptor can take various routes, as dictated by the physiology of a particular cell type. There is increasing evidence for a novel route which requires that a peptide hormone receptor pathway converge on a steroid hormone receptor, leading to its activation. One consequence of such a process can be signal amplification for the peptide hormone receptor agonist. This is exemplified by the self-potentiating action of GnRH, which is a critical component in events leading to a surge in LH secretion and ovulation. One signaling pathway stimulated by the GnRH receptor may entail a phosphorylation cascade resulting in progesterone-independent modulation of progesterone receptor activity.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume3
Issue number10
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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