Functional connectivity during masked and unmasked face emotion processing in bipolar disorder

Wan Ling Tseng, Laura A. Thomas, Elizabeth Harkins, Joel Stoddard, Carlos A. Zarate, Daniel S. Pine, Ellen Leibenluft, Melissa A. Brotman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to blank ovals. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume258
DOIs
StatePublished - Dec 30 2016
Externally publishedYes

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Bipolar Disorder
Emotions
Prefrontal Cortex
Amygdala
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • Backward masking
  • Bipolar disorder
  • Face emotion processing
  • Functional connectivity
  • Functional neuroimaging

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Tseng, W. L., Thomas, L. A., Harkins, E., Stoddard, J., Zarate, C. A., Pine, D. S., ... Brotman, M. A. (2016). Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Research - Neuroimaging, 258, 1-9. https://doi.org/10.1016/j.pscychresns.2016.10.006

Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. / Tseng, Wan Ling; Thomas, Laura A.; Harkins, Elizabeth; Stoddard, Joel; Zarate, Carlos A.; Pine, Daniel S.; Leibenluft, Ellen; Brotman, Melissa A.

In: Psychiatry Research - Neuroimaging, Vol. 258, 30.12.2016, p. 1-9.

Research output: Contribution to journalArticle

Tseng, WL, Thomas, LA, Harkins, E, Stoddard, J, Zarate, CA, Pine, DS, Leibenluft, E & Brotman, MA 2016, 'Functional connectivity during masked and unmasked face emotion processing in bipolar disorder', Psychiatry Research - Neuroimaging, vol. 258, pp. 1-9. https://doi.org/10.1016/j.pscychresns.2016.10.006
Tseng, Wan Ling ; Thomas, Laura A. ; Harkins, Elizabeth ; Stoddard, Joel ; Zarate, Carlos A. ; Pine, Daniel S. ; Leibenluft, Ellen ; Brotman, Melissa A. / Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. In: Psychiatry Research - Neuroimaging. 2016 ; Vol. 258. pp. 1-9.
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