Function without Structures: The Need for In-Depth Analysis of Dietary Carbohydrates

Matthew J. Amicucci; Eshani Nandita; Carlito B Lebrilla

doi:10.1021/acs.jafc.9b00720

Function without Structures: The Need for In-Depth Analysis of Dietary Carbohydrates

Matthew J. Amicucci, Eshani Nandita, Carlito B Lebrilla

Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Carbohydrates make up the largest component of plant-based foods and have long been known to provide fuel. However, many carbohydrates possess intrinsic biological activities that are dictated by their structures. Carbohydrates are the most abundant biopolymers in nature and are also the most structurally complicated and diverse. Consequently, the structural analysis of carbohydrates remains severely limited. To further understand their biological activities, we need new analytical tools to analyze the different classes of carbohydrates that range in size from monosaccharides to polysaccharides. These tools must be capable of rapid throughput with highly sensitive quantitation for use in clinical studies that probe their fate in human and animal fluids and tissues.

Original language	English (US)
Pages (from-to)	4418-4424
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	67
Issue number	16
DOIs	https://doi.org/10.1021/acs.jafc.9b00720
State	Published - Apr 24 2019

Keywords

carbohydrate
fiber
human milk
mass spectrometry
microbiome
monosaccharide
oligosaccharide
polysaccharide
prebiotic

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

Access to Document

10.1021/acs.jafc.9b00720

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abstract = "Carbohydrates make up the largest component of plant-based foods and have long been known to provide fuel. However, many carbohydrates possess intrinsic biological activities that are dictated by their structures. Carbohydrates are the most abundant biopolymers in nature and are also the most structurally complicated and diverse. Consequently, the structural analysis of carbohydrates remains severely limited. To further understand their biological activities, we need new analytical tools to analyze the different classes of carbohydrates that range in size from monosaccharides to polysaccharides. These tools must be capable of rapid throughput with highly sensitive quantitation for use in clinical studies that probe their fate in human and animal fluids and tissues.",

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