Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development

Achala De Mel, Bala Ramesh, David J. Scurr, Morgan R. Alexander, George Hamilton, Martin Birchall, Alexander M. Seifalian

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Replacement of irreversibly damaged organs due to chronic disease, with suitable tissue engineered implants is now a familiar area of interest to clinicians and multidisciplinary scientists. Ideal tissue engineering approaches require scaffolds to be tailor made to mimic physiological environments of interest with specific surface topographical and biological properties for optimal cell-material interactions. This study demonstrates a single-step procedure for inducing biomimcry in a novel nanocomposite base material scaffold, to re-create the extracellular matrix, which is required for stem cell integration and differentiation to mature cells. Fumed silica nanoparticle mediated procedure of scaffold functionalization, can be potentially adapted with multiple bioactive molecules to induce cellular biomimicry, in the development human organs. The proposed nanocomposite materials already in patients for number of implants, including world first synthetic trachea, tear ducts and vascular bypass graft. Amine functionalized fumed-silica nanoparticles can be used to integrate bioactive molecules which can be introduced to materials used for fabricating surgical implants and therefore induce biomimicry for greater cell-material interactions.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalMacromolecular Bioscience
Volume14
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Artificial Organs
Artificial organs
Nanocomposites
Cell Communication
Silicon Dioxide
Nanoparticles
Silica
Nasolacrimal Duct
Human Development
Tissue Engineering
Trachea
Scaffolds
Amines
Extracellular Matrix
Blood Vessels
Cell Differentiation
Chronic Disease
Stem Cells
Transplants
Molecules

Keywords

  • artificial-organs
  • bioactivity
  • biofunctionalization
  • fumed-silica
  • nanomaterials

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

De Mel, A., Ramesh, B., Scurr, D. J., Alexander, M. R., Hamilton, G., Birchall, M., & Seifalian, A. M. (2014). Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development. Macromolecular Bioscience, 14(3), 307-313. https://doi.org/10.1002/mabi.201300382

Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development. / De Mel, Achala; Ramesh, Bala; Scurr, David J.; Alexander, Morgan R.; Hamilton, George; Birchall, Martin; Seifalian, Alexander M.

In: Macromolecular Bioscience, Vol. 14, No. 3, 2014, p. 307-313.

Research output: Contribution to journalArticle

De Mel, A, Ramesh, B, Scurr, DJ, Alexander, MR, Hamilton, G, Birchall, M & Seifalian, AM 2014, 'Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development', Macromolecular Bioscience, vol. 14, no. 3, pp. 307-313. https://doi.org/10.1002/mabi.201300382
De Mel, Achala ; Ramesh, Bala ; Scurr, David J. ; Alexander, Morgan R. ; Hamilton, George ; Birchall, Martin ; Seifalian, Alexander M. / Fumed silica nanoparticle mediated biomimicry for optimal cell-material interactions for artificial organ development. In: Macromolecular Bioscience. 2014 ; Vol. 14, No. 3. pp. 307-313.
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