Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Jan Marik, Julie Sutcliffe

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalApplied Radiation and Isotopes
Volume65
Issue number2
DOIs
StatePublished - Feb 2007

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Keywords

  • 4-[F]fluorobenzoic acid
  • [F]FBA
  • [F]SFB
  • Chemistry process control unit (CPCU)
  • N-succinimidyl 4-[F]fluorobenzoate
  • Positron emission tomography PET

ASJC Scopus subject areas

  • Radiation

Cite this

Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU). / Marik, Jan; Sutcliffe, Julie.

In: Applied Radiation and Isotopes, Vol. 65, No. 2, 02.2007, p. 199-203.

Research output: Contribution to journal › Article

Marik, J & Sutcliffe, J 2007, 'Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)', Applied Radiation and Isotopes, vol. 65, no. 2, pp. 199-203. https://doi.org/10.1016/j.apradiso.2006.06.007
Marik J, Sutcliffe J. Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU). Applied Radiation and Isotopes. 2007 Feb;65(2):199-203. https://doi.org/10.1016/j.apradiso.2006.06.007
Marik, Jan ; Sutcliffe, Julie. / Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU). In: Applied Radiation and Isotopes. 2007 ; Vol. 65, No. 2. pp. 199-203.
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