Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Jan Marik, Julie Sutcliffe

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalApplied Radiation and Isotopes
Volume65
Issue number2
DOIs
StatePublished - Feb 2007

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Keywords

  • 4-[F]fluorobenzoic acid
  • [F]FBA
  • [F]SFB
  • Chemistry process control unit (CPCU)
  • N-succinimidyl 4-[F]fluorobenzoate
  • Positron emission tomography PET

ASJC Scopus subject areas

  • Radiation

Cite this

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title = "Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)",
abstract = "The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99{\%} with decay corrected yields of 77±5{\%} (n=4) for [18F]FBA and 46±5{\%} (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.",
keywords = "4-[F]fluorobenzoic acid, [F]FBA, [F]SFB, Chemistry process control unit (CPCU), N-succinimidyl 4-[F]fluorobenzoate, Positron emission tomography PET",
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AU - Marik, Jan

AU - Sutcliffe, Julie

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N2 - The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

AB - The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

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