Abstract
The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.
Original language | English (US) |
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Pages (from-to) | 199-203 |
Number of pages | 5 |
Journal | Applied Radiation and Isotopes |
Volume | 65 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- 4-[F]fluorobenzoic acid
- [F]FBA
- [F]SFB
- Chemistry process control unit (CPCU)
- N-succinimidyl 4-[F]fluorobenzoate
- Positron emission tomography PET
ASJC Scopus subject areas
- Radiation