Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Jan Marik; Julie Sutcliffe

doi:10.1016/j.apradiso.2006.06.007

Fully automated preparation of n.c.a. 4-[¹⁸F]fluorobenzoic acid and N-succinimidyl 4-[¹⁸F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Jan Marik, Julie Sutcliffe

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The widely used bifunctional labeling reagent 4-[¹⁸F]fluorobenzoic acid ([¹⁸F]FBA) and its activated form N-succinimidyl 4-[¹⁸F]fluorobenzoate ([¹⁸F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [¹⁸F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [¹⁸F]FBA and 46±5% (n=4) for [¹⁸F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

Original language	English (US)
Pages (from-to)	199-203
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/j.apradiso.2006.06.007
State	Published - Feb 2007

Keywords

4-[F]fluorobenzoic acid
[F]FBA
[F]SFB
Chemistry process control unit (CPCU)
N-succinimidyl 4-[F]fluorobenzoate
Positron emission tomography PET

ASJC Scopus subject areas

Radiation

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title = "Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)",

abstract = "The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.",

keywords = "4-[F]fluorobenzoic acid, [F]FBA, [F]SFB, Chemistry process control unit (CPCU), N-succinimidyl 4-[F]fluorobenzoate, Positron emission tomography PET",

author = "Jan Marik and Julie Sutcliffe",

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doi = "10.1016/j.apradiso.2006.06.007",

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journal = "Applied Radiation and Isotopes",

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AU - Sutcliffe, Julie

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Y1 - 2007/2

N2 - The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% (n=4) for [18F]FBA and 46±5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

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