Fructose mediated crosslinking of proteins.

D. J. Walton; John Douglas Mcpherson; B. H. Shilton

Fructose mediated crosslinking of proteins.

D. J. Walton, John Douglas Mcpherson, B. H. Shilton

Research output: Contribution to journal › Article

Abstract

10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.

Original language	English (US)
Pages (from-to)	163-170
Number of pages	8
Journal	Progress in Clinical and Biological Research
Volume	304
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Walton, D. J., Mcpherson, J. D., & Shilton, B. H. (1989). Fructose mediated crosslinking of proteins. Progress in Clinical and Biological Research, 304, 163-170.

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abstract = "10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.",

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year = "1989",

language = "English (US)",

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AU - Mcpherson, John Douglas

AU - Shilton, B. H.

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N2 - 10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.

AB - 10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.

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JO - Progress in Clinical and Biological Research

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