Fructose mediated crosslinking of proteins.

D. J. Walton, John Douglas Mcpherson, B. H. Shilton

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalProgress in Clinical and Biological Research
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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