Fructose-induced breath hydrogen in patients with fruit intolerance

Nirmal S Mann, Eddie C. Cheung

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


GOALS: To measure bloating score, flatus passage, and hydrogen production after oral fructose in patients with history of fruit intolerance and compare these parameters with those in normal controls. BACKGROUND: Some patients complain of abdominal distention and excessive flatus after ingesting certain fruits such as mango, persimmon, and grapes but not after eating apricots and melon. STUDY: We recorded breath hydrogen, flatus passage and bloating after 20 g fructose in 8 patients with history of fruit intolerance and 4 healthy controls. Breath hydrogen was measured every 15 minutes for 480 minutes using EC-60 gastrolyzer. Number of passage of flatus was recorded over 8 hours. Severity of abdominal distention on a scale of 1 to 10 was noted. RESULTS: The patients with fruit intolerance produced breath hydrogen 1745.2±7.8 parts per million, passed flatus 13.8±0.3 times, and had bloating score of 5.7±0.1. The healthy controls produced breath hydrogen 712.5±5.8 parts per million in 8 hours, passed flatus 7.2±0.5 time, and had bloating score of 2.7±0.2. CONCLUSIONS: After 20 g fructose, patients with history of fruit intolerance produce more breath hydrogen, pass flatus more frequently, and have a higher bloating score compared with healthy controls.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalJournal of Clinical Gastroenterology
Issue number2
StatePublished - Feb 2008


  • Bloating score
  • Breath hydrogen oral fructose
  • Flatus passage
  • Fruit intolerance

ASJC Scopus subject areas

  • Gastroenterology


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