Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia

A positron emission tomography study

John D Ragland, Ruben C. Gur, David C. Glahn, David M. Censits, Robin J. Smith, Mark G. Lazarev, Abass Alavi, Raquel E. Gur

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Schizophrenia affects prefrontal and temporal-limbic networks. These regions were examined by contrasting regional cerebral blood flow (rCBF) during executive (Wisconsin Card Sorting Test [WCST]), and declarative memory tasks (Paired Associate Recognition Test [PART]). The tasks, and a resting baseline, were administered to 15 patients with schizophrenia and 15 healthy controls during 10 min positron emission tomography 15O-water measures of rCBF. Patients were worse on both tasks. Controls activated inferior frontal, occipitotemporal, and temporal pole regions for both tasks. Similar results were obtained for controls matched to level of patient performance. Patients showed no activation of hypothesized regions during the WCST and activated the dorsolateral prefrontal cortex during the PART. On the PART, occipitotemporal activation correlated with better performance for controls only. Better WCST performance correlated with CBF increase in prefrontal regions for controls and in the parahippocampal gyrus for patients. Results suggest that schizophrenia may involve a breakdown in the integration of a frontotemporal network that is responsive to executive and declarative memory demands in healthy individuals.

Original languageEnglish (US)
Pages (from-to)399-413
Number of pages15
JournalNeuropsychology
Volume12
Issue number3
DOIs
StatePublished - Jul 1998
Externally publishedYes

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Cerebrovascular Circulation
Positron-Emission Tomography
Schizophrenia
Regional Blood Flow
Parahippocampal Gyrus
Temporal Lobe
Prefrontal Cortex
Water
Recognition (Psychology)

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology

Cite this

Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia : A positron emission tomography study. / Ragland, John D; Gur, Ruben C.; Glahn, David C.; Censits, David M.; Smith, Robin J.; Lazarev, Mark G.; Alavi, Abass; Gur, Raquel E.

In: Neuropsychology, Vol. 12, No. 3, 07.1998, p. 399-413.

Research output: Contribution to journalArticle

Ragland, John D ; Gur, Ruben C. ; Glahn, David C. ; Censits, David M. ; Smith, Robin J. ; Lazarev, Mark G. ; Alavi, Abass ; Gur, Raquel E. / Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia : A positron emission tomography study. In: Neuropsychology. 1998 ; Vol. 12, No. 3. pp. 399-413.
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